A Feasibility and Efficacy Randomized Controlled Trial of Two Exercise Programs in Severe AECOPD Patients with Resting Hypoxemia López López, Laura Calvache Mateo, Andrés Rodríguez-Torres, Janet Granados Santiago, María Ortiz Rubio, Araceli Valenza, Marie Carmen COPD Chronic Obstructive Pulmonary Disease Exacerbation Exercise training Hypoxemia NEMS Resting hypoxemia is the most severe stage of Chronic Obstructive Pulmonary Disease (COPD). Due to their impairments during the exacerbation, these patients are limited to traditional exercise rehabilitation and are excluded from the majority of the studies. The aim of this study was to assess the feasibility and the efficacy of two exercise programs in Acute Exacerbation of COPD (AECOPD) patients with resting hypoxemia. In this randomized clinical trial, patients hospitalized due to an acute exacerbation of COPD with hypoxemia at rest were included. Patients were randomly assigned into three groups. A Control Group (pharmacological treatment), a Global Exercise Group (GEG), and a Functional Electrostimulation Group (FEG). Patients were treated during the hospitalization period. The main outcomes were lower limb strength (assessed by a dynamometer), balance (assessed by the one leg standing balance test), health related quality of life (assessed by the EQ-5D), adverse events and adherence. At the end of the intervention, there were significant differences in all the variables in favour of the experimental groups (p < 0.05). We concluded that conducting an exercise program is feasible and improves lower limb strength, balance, and health related quality of life in AECOPD patients with resting hypoxemia. 2021-09-28T07:28:54Z 2021-09-28T07:28:54Z 2021 info:eu-repo/semantics/article López-López, L.; Calvache-Mateo, A.; Rodríguez-Torres, J.; Granados-Santiago, M.; Ortiz-Rubio, A.; Valenza, M.C. A Feasibility and Efficacy Randomized Controlled Trial of Two Exercise Programs in Severe AECOPD Patients with Resting Hypoxemia. Healthcare 2021, 9, 1102. https://doi.org/10.3390/healthcare 9091102 http://hdl.handle.net/10481/70483 10.3390/healthcare9091102 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI