Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing Melguizo Rodríguez, Lucía Raquel Luna Bertos, María Elvira De Ramos Torrecillas, Javier Illescas Montes, Rebeca Costela Ruiz, Víctor Javier García Martínez, Olga Extra virgin olive oil Phenolic compounds Wound healing Tissue regeneration This study was supported by research group BIO277 (Junta de Andalucia) and the Department of Nursing of the University of Granada. We would also like to thank Concepcion Ruiz for the considerations and retouches made to this paper. The treatment of tissue damage produced by physical, chemical, or mechanical agents involves considerable direct and indirect costs to health care systems. Wound healing involves a series of molecular and cellular events aimed at repairing the defect in tissue integrity. These events can be favored by various natural agents, including the polyphenols in extra virgin olive oil (EVOO). The objective of this study was to review data on the potential effects of different phenolic compounds that can also be found in EVOO on wound healing and closure. Results of in vitro and animal studies demonstrate that polyphenols from different plant species, also present in EVOO, participate in different aspects of wound healing, accelerating this process through their anti-inflammatory, antioxidant, and antimicrobial properties and their stimulation of angiogenic activities required for granulation tissue formation and wound re-epithelialization. These results indicate the potential usefulness of EVOO phenolic compounds for wound treatment, either alone or in combination with other therapies. Human studies are warranted to verify this proposition. 2021-09-20T06:41:34Z 2021-09-20T06:41:34Z 2021-07-15 info:eu-repo/semantics/article Melguizo-Rodríguez, L... [et al.]. Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing. Foods 2021, 10, 1642. [https://doi.org/10.3390/foods10071642] http://hdl.handle.net/10481/70283 10.3390/foods10071642 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI