Histamine: A Bacterial Signal Molecule Krell, Tino Gavira Gallardo, José Antonio Velando, Félix Fernández Rodríguez, Matilde Roca Hernández, Amalia de la Arrixac Monteagudo Cascales, Elizabet Matilla, Miguel A. Histamine Signal molecule Sensing Pseudomonas aeruginosa Histamine receptors Chemotaxis Gut microbiome This work was supported by FEDER funds and the Fondo Social Europeo through grants from the CSIC to M.A.M. (PIE-202040I003), the Spanish Ministry for Science, Innovation and Universities to M.A.M. (PID2019-103972GA-I00), the Junta de Andalucia to T.K. (P18-FR-1621) and Spanish Ministry of Economy and Competitiveness (BIO2016-76779-P to T.K. and BIO2016-74875-P to J.A.G.). A.R. was supported by the Spanish Ministry of Science and Innovation, Promotion of Talent and its Employability-Ramon y Cajal R&D&i Programme (RYC2019-026481-I). Bacteria have evolved sophisticated signaling mechanisms to coordinate interactions with organisms of other domains, such as plants, animals and human hosts. Several important signal molecules have been identified that are synthesized by members of different domains and that play important roles in inter-domain communication. In this article, we review recent data supporting that histamine is a signal molecule that may play an important role in inter-domain and inter-species communication. Histamine is a key signal molecule in humans, with multiple functions, such as being a neurotransmitter or modulator of immune responses. More recent studies have shown that bacteria have evolved different mechanisms to sense histamine or histamine metabolites. Histamine sensing in the human pathogen Pseudomonas aeruginosa was found to trigger chemoattraction to histamine and to regulate the expression of many virulence-related genes. Further studies have shown that many bacteria are able to synthesize and secrete histamine. The release of histamine by bacteria in the human gut was found to modulate the host immune responses and, at higher doses, to result in host pathologies. The elucidation of the role of histamine as an inter-domain signaling molecule is an emerging field of research and future investigation is required to assess its potential general nature. 2021-07-27T08:35:04Z 2021-07-27T08:35:04Z 2021-06-12 journal article Krell, T... [et al.]. Histamine: A Bacterial Signal Molecule. Int. J. Mol. Sci. 2021, 22, 6312. [https://doi.org/10.3390/ijms22126312] http://hdl.handle.net/10481/69929 10.3390/ijms22126312 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI