<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/69592">
      <dc:title>Study of Skin Barrier Function in Psoriasis: The Impact of Emollients</dc:title>
      <dc:creator>Maroto Morales, Daniel</dc:creator>
      <dc:creator>Montero Vilchez, Trinidad</dc:creator>
      <dc:creator>Arias Santiago, Salvador Antonio</dc:creator>
      <dc:subject>Emollients</dc:subject>
      <dc:subject>Homeostasis</dc:subject>
      <dc:subject>Moisturizers</dc:subject>
      <dc:subject>Psoriasis</dc:subject>
      <dc:subject>Skin physiology</dc:subject>
      <dc:subject>Skin barrier</dc:subject>
      <dc:description>Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier.&#xd;
Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about&#xd;
how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective&#xd;
of this study is to evaluate the effect of Vaseline jelly and a water-based formula on epidermal&#xd;
barrier function in psoriatic patients. Thirty-one patients with plaque-type psoriasis and thirty-one&#xd;
gender and age-matched healthy controls were enrolled in the study. Temperature, transepidermal&#xd;
water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity and the erythema index were&#xd;
measured using non-invasive tools before and after applying Vaseline jelly and a water-based formula.&#xd;
TEWL was higher in psoriatic plaques than uninvolved psoriatic skin (13.23 vs. 8.54 g·m−2&#xd;
·h&#xd;
−1&#xd;
;&#xd;
p &lt; 0.001). SCH was lower in psoriatic plaques than uninvolved psoriatic skin and healthy skin&#xd;
(13.44 vs. 30.55 vs. 30.90 arbitrary units (AU), p &lt; 0.001). In psoriatic plaques, TEWL decreased&#xd;
by 5.59 g·m−2&#xd;
·h&#xd;
−1&#xd;
(p = 0.001) after applying Vaseline Jelly, while it increased by 3.60 g·m−2&#xd;
·h&#xd;
−1&#xd;
(p = 0.006) after applying the water-based formula. SCH increased by 9.44 AU after applying the&#xd;
water-based formula (p = 0.003). The use of emollients may improve epidermal barrier function&#xd;
in psoriatic patients. TEWL is decreased by using Vaseline, and SCH is increased by using the&#xd;
water-based formula</dc:description>
      <dc:date>2021-07-07T10:37:05Z</dc:date>
      <dc:date>2021-07-07T10:37:05Z</dc:date>
      <dc:date>2021</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Maroto-Morales, D.; Montero-Vilchez, T.; Arias-Santiago, S. Study of Skin Barrier Function in Psoriasis: The Impact of Emollients. Life 2021, 11, 651. https://doi.org/ 10.3390/life11070651</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/69592</dc:identifier>
      <dc:identifier>10.3390/life11070651</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>