On the Use of a Multimodal Optimizer for Fitting Neuron Models. Application to the Cerebellar Granule Cell Marín Alejo, Milagros Cruz, Nicolás C. Martínez Ortigosa, Eva Sáez Lara, María José Garrido Alcázar, Jesús Alberto Carrillo Sánchez, Richard Rafael Granule cell Cerebellum Neuron model Optimization Adaptive exponential integrate-and-fire Multimodal evolutionary algorithm This article integrates work from authors from different research groups and has been funded by the EU Grant HBP (H2020 SGA3. 945539), the Spanish Ministry of Economy and Competitiveness (RTI2018-095993-B-I00), the national grant INTSENSO (MICINN-FEDER-PID2019-109991GB-I00), the regional grants of Junta de Andalucia (CEREBIO: JA FEDER P18-FR-2378, P18-RT-1193, and A-TIC-276-UGR18), and the University of Almeria (UAL18-TIC-A020-B). This article extends a recent methodological workflow for creating realistic and computationally efficient neuron models whilst capturing essential aspects of singleneuron dynamics. We overcome the intrinsic limitations of the extant optimization methods by proposing an alternative optimization component based on multimodal algorithms. This approach can natively explore a diverse population of neuron model configurations. In contrast to methods that focus on a single global optimum, the multimodal method allows directly obtaining a set of promising solutions for a single but complex multi-feature objective function. The final sparse population of candidate solutions has to be analyzed and evaluated according to the biological plausibility and their objective to the target features by the expert. In order to illustrate the value of this approach, we base our proposal on the optimization of cerebellar granule cell (GrC) models that replicate the essential properties of the biological cell. Our results show the emerging variability of plausible sets of values that this type of neuron can adopt underlying complex spiking characteristics. Also, the set of selected cerebellar GrC models captured spiking dynamics closer to the reference model than the single model obtained with off-the-shelf parameter optimization algorithms used in our previous article. The method hereby proposed represents a valuable strategy for adjusting a varied population of realistic and simplified neuron models. It can be applied to other kinds of neuron models and biological contexts. 2021-07-06T08:14:43Z 2021-07-06T08:14:43Z 2021-06-03 info:eu-repo/semantics/article Marín M... [et al.] (2021) On the Use of a Multimodal Optimizer for Fitting Neuron Models. Application to the Cerebellar Granule Cell. Front. Neuroinform. 15:663797. doi: [10.3389/fninf.2021.663797] http://hdl.handle.net/10481/69540 10.3389/fninf.2021.663797 eng info:eu-repo/grantAgreement/EC/H2020/945539 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Frontiers Research Foundation