Synthesis and screening of 6‐alkoxy purine analogs as cell type‐selective apoptotic inducers in Jurkat cells Lorente Macías, Álvaro Iáñez García, Inmaculada Jiménez López, M. Carmen Benítez Quesada, Manuel Torres Rusillo, Sara Díaz Mochón, Juan José Molina Pineda Infantas, Ignacio Jesús Pineda De Las Infant Y Villatoro, María José Anticancer drugs Apoptosis Leukemia Phenotypic screening Purine analogs Ministerio de Ciencia e Innovacion, Grant/Award Number: RTC-2017-6620; Ministerio de Educacion, Cultura y Deporte, Grant/Award Number: FPU 14/00818 Purines are ubiquitous structures in cell biology involved in a multitude of cellular processes, because of which substituted purines and analogs are considered excellent scaffolds in drug design. In this study, we explored the key structural features of a purine‐based proapoptotic hit, 8‐tert‐butyl‐9‐phenyl‐6‐benzyloxy‐9Hpurine (1), by setting up a library of 6‐alkoxy purines with the aim of elucidating the structural requirements that govern its biological activity and to study the cell selectivity of this chemotype. This was done by a phenotypic screening approach based on cell cycle analysis of a panel of six human cancer cell lines, including T cell leukemia Jurkat cells. From this study, two derivatives (12 and 13) were identified as Jurkat‐selective proapoptotic compounds, displaying superior potency and cell selectivity than hit 1. 2021-07-02T08:41:27Z 2021-07-02T08:41:27Z 2021-06-15 journal article Á. Lorente‐Macías... [et al.]. Synthesis and screening of 6‐alkoxy purine analogs as cell type‐selective apoptotic inducers in Jurkat cells. Arch. Pharm. 2021, e2100095. [https://doi.org/10.1002/ardp.202100095] http://hdl.handle.net/10481/69469 10.1002/ardp.202100095 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Wiley-VCH Verlag GmbH