Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial González Santos, Ángela Postigo Martín, Elisa Paula Gallart Aragón, Tania Esteban Cornejo, Irene López Garzón, María de la Cabeza Galiano Castillo, Noelia Arroyo Morales, Manuel Illescas Montes, Rebeca Artacho Cordón, Francisco Martín Martín, Lydia María Forneiro Pérez, Rocío Lozano Lozano, Mario Fernández Lao, Carolina Ruiz Vozmediano, Julia Sánchez Salgado, Carmen Cantarero Villanueva, Irene Breast neoplasms Neurotoxicity Prehabilitation Quality of life Therapeutic exercise The authors thank the Asociación Española Contra el Cáncer (IDEAS19055CANT), the Spanish Ministry of Education Culture and Sport (MECD) (FPU17/00939, FPU18/03575), the Carlos III Health Institute (FI19/00230), and Carlos III Health Insitute and the European Regional Development Fund (FEDER) (PI18/01840), for funding this study and all participants of the study. IEC is supported by the Spanish Ministry of Economy and Competitiveness. This study was part of a Ph.D thesis conducted in the Clinical Medicine and Public Health Doctoral Studies of the University of Granada, Spain. Trial registration: ClinicalTrials. Gov identifier: NCT04583124. A current challenge in breast cancer (BC) patients is how to reduce the side effects of cancer and cancer treatments and prevent a decrease in quality of life (QoL). Neurotoxic side effects, especially from chemotherapy, are present in up to 75% of women with BC, which implies a large impact on QoL. There is a special interest in the preventive possibilities of therapeutic exercise (TE) for these neurological sequelae, and the benefits of TE could be improved when it is combined with vagal activation techniques (VATs). This superiority randomized controlled trial aims to examine the feasibility and efficacy of an 8-week multimodal intervention (ATENTO) based on moderate-vigorous intensity and individualized TE (aerobic and strength exercises) and VAT (myofascial and breathing exercises), on neurotoxicity prevention in women with BC before starting adjuvant chemotherapy (ATENTO-B) versus throughout adjuvant chemotherapy (ATENTO-T). A sample of 56 women newly diagnosed with BC, as calculated with a power of 85%, will be randomly allocated into these two groups. This study could provide an impetus for the introduction of early multimodal intervention methods to prevent neurotoxicity and consequently avoid the QoL deterioration that BC patients presently suffer throughout their treatments. 2021-06-02T08:24:10Z 2021-06-02T08:24:10Z 2021-05-07 info:eu-repo/semantics/article González‐Santos, Á., Postigo‐Martin, P., Gallart‐Aragón, T., Esteban‐Cornejo, I., Lopez‐Garzon, M., Galiano‐Castillo, N., Arroyo‐Morales, M., Illescas‐Montes, R., Artacho‐Cordón, F., Martín‐Martín, L., Forneiro‐Pérez, R., Lozano‐Lozano, M., Fernández‐Lao, C., Ruiz‐Vozmediano, J., Sánchez‐Salgado, C., & Cantarero‐Villanueva, I. (2021). Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial. Research in Nursing & Health, 1–10. [https://doi.org/10.1002/nur.22136] http://hdl.handle.net/10481/68984 10.1002/nur.22136 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España John Wiley & Sons