Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment Galbán Velázquez, Suylen Artacho Cordón, Francisco León López, Josefa Vela Soria, Fernando Martín-Olmedo, Piedad Fernández Cabrera, Mariana Fátima Arrebola Moreno, Juan Pedro Persistent organic pollutants Polychlorinated biphenyls Retinoid system Superoxide dismutase Oxidative stress This work was supported by research grants from CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Junta de Andalucia, European Regional Development Fund-FEDER (PI16/01858, PI16/01812, PI20/01568 and PI-13/02406) and Generalitat Valenciana. Dr. G Cakmak is awarded a grant by The Scientific and Technological Research Council of Turkey (TUBITAK-2219). Dr. JP Arrebola is under contract within the Ramón y Cajal Program (RYC-2016-20155, Ministerio de Economia, Industria y Competitividad, Spain). These results would not have been achieved without the selfless collaboration of the staff from Santa Ana and San Cecilio Hospitals and the participants who took part in the study. Humans are exposed to a myriad of chemical substances in both occupational and environmental settings. Persistent organic pollutants (POPs) have drawn attention for their adverse effects including cancer and endocrine disruption. Herein, the objectives were 1) to describe serum and adipose tissue retinol levels, along with serum retinol binding protein 4 (RBP4) concentrations, and 2) to assess the associations of adipose tissue POP levels with these retinoid parameters, as well as their potential interaction with the previously-observed POP-related disruption of redox microenvironment. Retinol was measured in both serum and adipose tissue along with RBP4 levels in serum samples of 236 participants of the GraMo adult cohort. Associations were explored by multivariable linear regression analyses and Weighted Quantile Sum regression. Polychlorinated biphenyls (PCBs) 180, 153 and 138 were related to decreased adipose tissue retinol levels and increased serum RBP4/retinol ratio. Dicofol concentrations > limit of detection were associated with decreased retinol levels in serum and adipose tissue. Additionally, increased adipose tissue retinol levels were linked to an attenuation in previously-reported associations of adipose tissue PCB-153 with in situ superoxide dismutase activity. Our results revealed a suggestive link between retinoids, PCBs and redox microenvironment, potentially relevant for both mechanistic and public health purposes. 2021-05-28T07:29:19Z 2021-05-28T07:29:19Z 2021-01-23 info:eu-repo/semantics/article Suylen Galbán-Velázquez, Javier Esteban, Gonca Çakmak, Francisco Artacho-Cordón, Josefa León, Jose Barril, Fernando Vela-Soria, Piedad Martin-Olmedo, Mariana F. Fernandez, M. Cruz Pellín, Juan P. Arrebola, Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment, Environmental Research, Volume 195, 2021, 110764, ISSN 0013-9351, [https://doi.org/10.1016/j.envres.2021.110764] http://hdl.handle.net/10481/68820 10.1016/j.envres.2021.110764 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España Elsevier