MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy Aránega, Amelia Eva Lozano Velasco, Estefanía Rodríguez Outeiriño, Lara Ramírez de Acuña, Felicitas Franco, Diego Hernández Torres, Francisco MicroRNA Satellite cell Myogenesis Muscle regeneration Muscular dystrophies This research was funded by Duchenne Parent Project Espana grants 2016, 2018 and 2019. microRNAs (miRNAs) are small non-coding RNAs required for the post-transcriptional control of gene expression. MicroRNAs play a critical role in modulating muscle regeneration and stem cell behavior. Muscle regeneration is affected in muscular dystrophies, and a critical point for the development of effective strategies for treating muscle disorders is optimizing approaches to target muscle stem cells in order to increase the ability to regenerate lost tissue. Within this framework, miRNAs are emerging as implicated in muscle stem cell response in neuromuscular disorders and new methodologies to regulate the expression of key microRNAs are coming up. In this review, we summarize recent advances highlighting the potential of miRNAs to be used in conjunction with gene replacement therapies, in order to improve muscle regeneration in the context of Duchenne Muscular Dystrophy (DMD). 2021-05-27T08:12:17Z 2021-05-27T08:12:17Z 2021-04-19 info:eu-repo/semantics/article Aránega, A.E.; Lozano- Velasco, E.; Rodriguez-Outeiriño, L.; Ramírez de Acuña, F.; Franco, D.; Hernández-Torres, F. MiRNAs and Muscle Regeneration: Therapeutic Targets in Duchenne Muscular Dystrophy. Int. J. Mol. Sci. 2021, 22, 4236. [https://doi.org/10.3390/ijms22084236] http://hdl.handle.net/10481/68764 10.3390/ijms22084236 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI