Psychosis and Dandy-Walker syndrome: a case report and review of the literature Porras Segovia, Alejandro Guerrero Jiménez, Margarita Carrillo de Albornoz Calahorro, Carmen Maura Gutiérrez Rojas, Luis Psychotic disorders Schizophrenia Schizophrenia spectrum and other psychotic disorders Cerebellar vermis Cerebral ventricles Dandy-Walker syndrome (DWS) is a group of brain malformations which sometimes present with psychotic symptoms. We present the case of a patient diagnosed with Dandy-Walker variant who presented with schizophrenia-like psychosis. A man in his 30s was admitted to an acute psychiatric unit presenting with persecutory delusions, auditory hallucinations and violent behaviour. The MRI performed showed the typical alterations of Dandy-Walker variant: vermian hypoplasia and cystic dilatation of the fourth ventricle. He also suffered from mild intellectual disability. After being treated with olanzapine 10 mg/d for a month, his psychotic symptoms greatly improved and he was discharged. In conclusion, DWS may cause psychosis through a dysfunction in the circuit connecting prefrontal, thalamic and cerebellar areas. The association between these two conditions may contribute to the understanding of the aetiopathogenesis of schizophrenia. 2021-05-12T07:34:25Z 2021-05-12T07:34:25Z 2021-04-14 info:eu-repo/semantics/article Porras Segovia A, Guerrero-Jiménez M, Carrillo de Albornoz Calahorro CM, et al. Psychosis and Dandy-Walker syndrome: a case report and review of the literature. General Psychiatry 2021;34:e100254. doi:[10.1136/gpsych-2020-100254] http://hdl.handle.net/10481/68483 10.1136/gpsych-2020-100254 eng http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial 3.0 España BMJ