Relative Handgrip Strength as Marker of Cardiometabolic Risk in Women with Systemic Lupus Erythematosus Sola Rodríguez, Sergio Gavilán Carrera, Blanca Ortego Centeno, Norberto Autoimmune diseases Cardiovascular risk Muscle strength Body mass index Metabolism Cardiovascular disease Lupus Risk factors This study aimed to examine the association of relative handgrip strength (rHGS) with cardiometabolic disease risk factors in women with systemic lupus erythematosus (SLE). Methods: Seventy-seven women with SLE (mean age 43.2, SD 13.8) and clinical stability during the previous six months were included. Handgrip strength was assessed with a digital dynamometer and rHGS was defined as absolute handgrip strength (aHGS) divided by body mass index (BMI). We measured blood pressure, markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]), arterial stiffness (pulse wave velocity [PWV]), and renal function. A clustered cardiometabolic risk index (z-score) was computed. Results: Pearson0 s bivariate correlations revealed that higher rHGS was associated with lower systolic blood pressure (SBP), triglycerides, hs-CRP, PWV, and lower clustered cardiometabolic risk (rrange = from −0.43 to −0.23; all p < 0.05). Multivariable linear regression analyses adjusted for age, disease activity (SLEDAI), and accrual damage (SDI) confirmed these results (all p < 0.05) except for triglycerides. Conclusions: The findings suggest that higher rHGS is significantly associated with lower cardiometabolic risk in women with SLE. 2021-05-11T09:10:46Z 2021-05-11T09:10:46Z 2021 journal article Sola-Rodríguez, S.; Vargas-Hitos, J.A.; Gavilán-Carrera, B.; Rosales-Castillo, A.; Sabio, J.M.; Hernández-Martínez, A.; Martínez-Rosales, E.; Ortego-Centeno, N.; Soriano-Maldonado, A. Relative Handgrip Strength as Marker of Cardiometabolic Risk in Women with Systemic Lupus Erythematosus. Int. J. Environ. Res. Public Health 2021, 18, 4630. https://doi.org/10.3390/ ijerph18094630 http://hdl.handle.net/10481/68455 10.3390/ijerph18094630 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI