Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis López Moreno, Ana Aguilera Gómez, Margarita Vaginal probiotics Reproductive dysbiosis Bacterial vaginosis VVC IVF This research received no direct external funding. A.L.-M. was granted with the IniciaTC programme—OTRI-UGR. Infrastructure Reference Microbiota Laboratory funding projects FEDERIE_ 2019-198 and EIN-2019-103082. The authors acknowledge support from the Programs IniciaTC 2019, and INV 2019–2021 from the Plan Propio of the University of Granada. Part of results is from Ana López- Moreno doctoral thesis, Biomedicine Doctorate Program of the University of Granada. The use of probiotics in reproductive-related dysbiosis is an area of continuous progress due to the growing interest from clinicians and patients suffering from recurrent reproductive microbiota disorders. An imbalance in the natural colonization sites related to reproductive health-vaginal, cervicovaginal, endometrial, and pregnancy-related altered microbiota-could play a decisive role in reproductive outcomes. Oral and vaginal administrations are in continuous discussion regarding the clinical effects pursued, but the oral route is used and studied more often despite the need for further transference to the colonization site. The aim of the present review was to retrieve the standardized protocols of vaginal probiotics commonly used for investigating their microbiota modulation capacities. Most of the studies selected focused on treating bacterial vaginosis (BV) as the most common dysbiosis; a few studies focused on vulvovaginal candidiasis (VVC) and on pretreatment during in vitro fertilization (IVF). Vaginal probiotic doses administered were similar to oral probiotics protocols, ranging from >= 10(7) CFU/day to 2.5 x 10(10) CFU/day, but were highly variable regarding the treatment duration timing. Moderate vaginal microbiota modulation was achieved; the relative abundance of abnormal microbiota decreased and Lactobacillus species increased. 2021-05-10T12:15:25Z 2021-05-10T12:15:25Z 2021-04-02 info:eu-repo/semantics/article López-Moreno, A.; Aguilera, M. Vaginal Probiotics for Reproductive Health and Related Dysbiosis: Systematic Review and Meta-Analysis. J. Clin. Med. 2021, 10, 1461. [https://doi.org/10.3390/jcm10071461] http://hdl.handle.net/10481/68439 10.3390/jcm10071461 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI