Synergistic Photothermal-Chemotherapy Based on the Use of Biomimetic Magnetic Nanoparticles Jabalera Ruz, Ylenia María Sola Leyva, Alberto Carrasco Jiménez, María Paz Iglesias Salto, Guillermo Ramón Jiménez López, Concepción Biomimetic magnetic nanoparticles Combined tumor therapy Doxorubicin HepG2 cancer cell line MamC Magnetite nanoparticles Photothermia MamC-mediated biomimetic magnetic nanoparticles (BMNPs) have emerged as one of the most promising nanomaterials due to their magnetic features (superparamagnetic character and large magnetic moment per particle), their novel surface properties determined by MamC, their biocompatibility and their ability as magnetic hyperthermia agents. However, the current clinical application of magnetic hyperthermia is limited due to the fact that, in order to be able to reach an effective temperature at the target site, relatively high nanoparticle concentration, as well as high magnetic field strength and/or AC frequency are needed. In the present study, the potential of BMNPs to increase the temperature upon irradiation of a laser beam in the near infrared, at a wavelength at which tissues become partially transparent, is explored. Moreover, our results also demonstrate the synergy between photothermia and chemotherapy in terms of drug release and cytotoxicity, by using BMNPs functionalized with doxorubicin, and the effectiveness of this combination therapy against tumor cells in in vitro experiments. Therefore, the findings of the present study open the possibility of a novel, alternative approach to fight localized tumors. 2021-05-10T12:05:23Z 2021-05-10T12:05:23Z 2021 info:eu-repo/semantics/article Jabalera, Y.; Sola-Leyva, A.; Carrasco-Jiménez, M.P.; Iglesias, G.R.; Jimenez-Lopez, C. Synergistic Photothermal-Chemotherapy Based on the Use of Biomimetic Magnetic Nanoparticles. Pharmaceutics 2021, 13, 625. https://doi.org/10.3390/ pharmaceutics13050625 http://hdl.handle.net/10481/68438 10.3390/pharmaceutics13050625 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI