<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/67829">
      <dc:title>Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study</dc:title>
      <dc:creator>Seral Cortes, Miguel</dc:creator>
      <dc:creator>Molina Hidalgo, Cristina</dc:creator>
      <dc:creator>Ruiz Ruiz, Jonatan</dc:creator>
      <dc:description>Obesity is the result of interactions between genes and environmental factors. Since monogenic&#xd;
etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful&#xd;
to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a&#xd;
GRS able to predict genetic predisposition to overweight and obesity in European adolescents. A&#xd;
total of 1069 adolescents (51.3% female), aged 11–19 years participating in the Healthy Lifestyle in&#xd;
Europe by Nutrition in Adolescence (HELENA) cross-sectional study were genotyped. The sample&#xd;
was divided in non-overweight (non-OW) and overweight/obesity (OW/OB). From 611 single&#xd;
nucleotide polymorphisms (SNP) available, a first screening of 104 SNPs univariately associated with&#xd;
obesity (p &lt; 0.20) was established selecting 21 significant SNPs (p &lt; 0.05) in the multivariate model.&#xd;
Unweighted GRS (uGRS) was calculated by summing the number of risk alleles and weighted GRS&#xd;
(wGRS) by multiplying the risk alleles to each estimated coefficient. The area under curve (AUC) was&#xd;
calculated in uGRS (0.723) and wGRS (0.734) using tenfold internal cross-validation. Both uGRS and&#xd;
wGRS were significantly associated with body mass index (BMI) (p &lt; .001). Both GRSs could potentially&#xd;
be considered as useful genetic tools to evaluate individual’s predisposition to overweight/obesity in&#xd;
European adolescents.</dc:description>
      <dc:date>2021-04-07T09:39:36Z</dc:date>
      <dc:date>2021-04-07T09:39:36Z</dc:date>
      <dc:date>2021-02-04</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Seral-Cortes, M., Sabroso-Lasa, S., De Miguel-Etayo, P., Gonzalez-Gross, M., Gesteiro, E., Molina-Hidalgo, C., ... &amp; Labayen, I. (2021). Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study. Scientific reports, 11(1), 1-11. [https://doi.org/10.1038/s41598-021-82712-4]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/67829</dc:identifier>
      <dc:identifier>10.1038/s41598-021-82712-4</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Nature Research</dc:publisher>
   </ow:Publication>
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