Mediterranean Diet, Screen-Time-Based Sedentary Behavior and Their Interaction Effect on Adiposity in European Adolescents: The HELENA Study Seral Cortes, Miguel Molina Hidalgo, Cristina Mediterranean diet Sedentary time Adiposity Adolescents Gender and HELENA Childhood obesity is a worldwide epidemic. Mediterranean diet (MD) is inversely associated with childhood obesity, but the interaction with other environmental factors, such screen time, might influence the health benefits of a highMD adherence in adolescents. The aimof the present studywas to assess whether an association between MD and screen time exists in European adolescents. Moreover, we also explored whether sedentary time has a modulatory effect on the association between MD and adiposity. Adherence to the MD (24 h recalls), screen time (questionnaire), pubertal development, body mass index (BMI), fat mass index (FMI) and waist circumference (WC) were evaluated in 2053 adolescents (54.7% females), aged 12.5–17.5 years. In females, MD adherence was associated with lower BMI and FMI only when they were exposed to less than 338 min/day of screen time (81.8% of females);MD adherence was also associated with lowerWC only when females were exposed to less than 143 min/day of screen time (31.5% of females). No significantMD-screen time interaction was observed in males. In conclusion, screen-time-based sedentary behaviours had a modulatory effect in the association between MD adherence and adiposity in European female adolescents. 2021-04-07T09:25:02Z 2021-04-07T09:25:02Z 2021-01-30 info:eu-repo/semantics/article Seral-Cortes, M.; Sabroso-Lasa, S.; Bailo-Aysa, A.; Gonzalez-Gross, M.; Molnár, D.; Censi, L.; Molina-Hidalgo, C.; Gottrand, F.; Henauw, S.D.; Manios, Y.; et al. Mediterranean Diet, Screen-Time-Based Sedentary Behavior and Their Interaction Effect on Adiposity in European Adolescents: The HELENA Study. Nutrients 2021, 13, 474. [https://doi.org/10.3390/nu13020474] http://hdl.handle.net/10481/67822 10.3390/nu13020474 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Mdpi