Enhanced Stability Against Radiation Damage of Lysozyme Crys-tals Grown in Fmoc-CF Hydrogels Álvarez Cienfuegos Rodríguez, Luis Lysozyme crystals grown in Fmoc-CF (Cys-Phe) hydro-gels, unlike those grown in agarose, give rise to compo-site crystals that have an enhanced resistance against degradation caused by an intense exposure to X-ray irradiation. Fmoc-CF dipeptide shows a clear protection of the most sensitive groups (disulfide bonds and methi-onines) of the protein. The protection mediated by cys-teine is exerted only in its gel state since cysteine in solution has an adverse effect. Probably the reactive thiols groups of cysteine being locked within the rigid peptide fibers minimize cross-reactions with the proteins favoring the formation of protein crystals. Once located inside the protein crystal the long peptide fibers are able to protect the protein against radiation damage. 2021-04-06T07:44:51Z 2021-04-06T07:44:51Z 2019 info:eu-repo/semantics/article Cryst. Growth Des. 2019, 19, 4229−4233 http://hdl.handle.net/10481/67798 10.1021/acs.cgd.9b00131 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España ACS