Zn-doping of silicate and hydroxyapatite-based cements: dentin mechanobiology and bioactivity Toledano Pérez, Manuel Osorio Ruiz, Raquel Vallecillo-Rivas, Marta Osorio Ruiz, María Estrella Lynch, Christopher D. Aguilera, Fátima S. Toledano, Raquel Sauro, Salvatore Zinc Cement Dentin Remineralization Bioactivity This work was supported by the Ministry of Economy and Competitiveness and European Regional Development Fund [MAT2017-85999PMINECO/AEI/FEDER/UE]. The authors affirm that no actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work. Any other potential conflict of interest is disclosed. The objective was to state zinc contribution in the effectiveness of novel zinc-doped dentin cements to achieve dentin remineralization, throughout a literature or narrative exploratory review. Literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI, Embase, Scopus and Web of Science. Both zinc-doping silicate and hydroxyapatite-based cements provoked an increase of both bioactivity and intrafibrillar mineralization of dentin. Zinc-doped hydroxyapatite-based cements (oxipatite) also induced an increase in values of dentin nano-hardness, Young’s modulus and dentin resistance to deformation. From Raman analyses, it was stated higher intensity of phosphate peaks and crystallinity as markers of dentin calcification, in the presence of zinc. Zinc-based salt formations produced low microleakage and permeability values with hermetically sealed tubules at radicular dentin. Dentin treated with oxipatite attained preferred crystal grain orientation with polycrystalline lattices. Thereby, oxipatite mechanically reinforced dentin structure, by remineralization. Dentin treated with oxipatite produced immature crystallites formations, accounting for high hydroxyapatite solubility, instability and enhanced remineralizing activity. 2021-03-11T12:07:05Z 2021-03-11T12:07:05Z 2020-12 info:eu-repo/semantics/article Publisher version: Toledano M, Osorio R, Vallecillo-Rivas M, Osorio E, Lynch CD, Aguilera FS, Toledano R, Sauro S. Zn-doping of silicate and hydroxyapatite-based cements: Dentin mechanobiology and bioactivity. Journal of the Mechanical Behavior of Biomedical Materials. 2021;114:104232. http://hdl.handle.net/10481/67105 https://doi.org/10.1016/j.jmbbm.2020.104232 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España