Skin Barrier Function in Psoriasis and Atopic Dermatitis: TransepidermalWater Loss and Temperature as Useful Tools to Assess Disease Severity Montero Vilchez, Trinidad Segura Fernández-Nogueras, María Victoria Pérez Rodríguez, Isabel Soler Góngora, Miguel Martínez López, Antonio Fernández González, Ana Molina Leyva, Alejandro Arias Santiago, Salvador Antonio Atopic dermatitis Homeostasis Psoriasis Skin barrier Transepidermal water loss Multiple diagnostic tools are used to evaluate psoriasis and atopic dermatitis (AD) severity, but most of them are based on subjective components. Transepidermal water loss (TEWL) and temperature are skin barrier function parameters that can be objectively measured and could help clinicians to evaluate disease severity accurately. Thus, the aims of this study are: (1) to compare skin barrier function between healthy skin, psoriatic skin and AD skin; and (2) to assess if skin barrier function parameters could predict disease severity. A cross-sectional study was designed, and epidermal barrier function parameters were measured. The study included 314 participants: 157 healthy individuals, 92 psoriatic patients, and 65 atopic dermatitis patients. TEWL was significantly higher, while stratum corneum hydration (SCH) (8.71 vs. 38.43 vs. 44.39 Arbitrary Units (AU)) was lower at psoriatic plaques than at uninvolved psoriatic skin and healthy controls. Patients with both TEWL > 13.85 g m-2h-1 and temperature > 30.85 C presented a moderate/severe psoriasis (psoriasis area severity index (PASI) 7), with a specificity of 76.3%. TEWL (28.68 vs. 13.15 vs. 11.60 g m-2 h-1) and temperature were significantly higher, while SCH (25.20 vs. 40.95 vs. 50.73 AU) was lower at AD eczematous lesions than uninvolved AD skin and healthy controls. Patients with a temperature > 31.75 C presented a moderate/severe AD (SCORing Atopic Dermatitis (SCORAD) 37) with a sensitivity of 81.8%. In conclusion, temperature and TEWL values may help clinicians to determine disease severity and select patients who need intensive treatment. 2021-03-05T12:27:11Z 2021-03-05T12:27:11Z 2021-01-19 info:eu-repo/semantics/article Montero-Vilchez, T.; Segura-Fernández-Nogueras, M.-V.; Pérez-Rodríguez, I.; Soler-Gongora, M.; Martinez-Lopez, A.; Fernández-González, A.; Molina-Leyva, A.; Arias-Santiago, S. Skin Barrier Function in Psoriasis and Atopic Dermatitis: Transepidermal Water Loss and Temperature as Useful Tools to Assess Disease Severity. J. Clin. Med. 2021, 10, 359. [https://doi.org/10.3390/jcm10020359] http://hdl.handle.net/10481/66932 10.3390/jcm10020359 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Mdpi