<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/66427">
      <dc:title>Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study</dc:title>
      <dc:creator>Seral Cortes, Miguel</dc:creator>
      <dc:creator>Molina Hidalgo, Cristina</dc:creator>
      <dc:subject>Metabolic syndrome</dc:subject>
      <dc:subject>Mediterranean diet</dc:subject>
      <dc:subject>Genetic risk score</dc:subject>
      <dc:subject>Helena</dc:subject>
      <dc:subject>Adolescents</dc:subject>
      <dc:subject>Sex</dc:subject>
      <dc:description>Obesity and metabolic syndrome (MetS) are worldwide major health challenges.&#xd;
The Mediterranean diet (MD) is associated with a better cardiometabolic profile, but these beneficial&#xd;
e ects may be influenced by genetic variations, modulating the predisposition to obesity or MetS.&#xd;
The aim was to assess whether interaction e ects occur between an obesity genetic risk score&#xd;
(obesity-GRS) and the MD on adiposity and MetS in European adolescents. Multiple linear regression&#xd;
models were used to assess the interaction e ects of an obesity-GRS and the MD on adiposity and&#xd;
MetS and its components. Interaction e ects between theMDon adiposity and MetS were observed in&#xd;
both sex groups (p &lt; 0.05). However, those interaction e ects were only expressed in a certain number&#xd;
of adolescents, when a limited number of risk alleles were present. Regarding adiposity, a total of&#xd;
51.1% males and 98.7% females had lower body mass index (BMI) as a result of higher MD adherence.&#xd;
Concerning MetS, only 9.9% of males with higher MD adherence had lower MetS scores. However,&#xd;
the same e ect was observed in 95.2% of females. In conclusion, obesity-related genotypes could&#xd;
modulate the relationship between MD adherence and adiposity and MetS in European adolescents;&#xd;
the interaction e ect was higher in females than in males.</dc:description>
      <dc:date>2021-02-10T09:46:01Z</dc:date>
      <dc:date>2021-02-10T09:46:01Z</dc:date>
      <dc:date>2020-12-16</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Seral-Cortes, M., Sabroso-Lasa, S., Miguel-Etayo, D., Gonzalez-Gross, M., Gesteiro, E., Molina-Hidalgo, C., ... &amp; Labayen, I. (2020). Interaction Effect of the Mediterranean Diet and an Obesity Genetic Risk Score on Adiposity and Metabolic Syndrome in Adolescents: The HELENA Study. Nutrients, 12(12), 3841. [doi:10.3390/nu12123841]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/66427</dc:identifier>
      <dc:identifier>10.3390/nu12123841</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Mdpi</dc:publisher>
   </ow:Publication>
</rdf:RDF>