Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study Pérez Castillo, Íñigo María Rivero Blanco, Tania León Ríos, Ximena Alejandra Expósito Ruiz, Manuela López Criado, María Setefilla Aguilar Cordero, María José vitamin D deficiency Perinatal adverse outcomes 25-hydroxyvitamin D Parathyroid hormone PTH Calcium Phosphorus Cohort study Vitamin D deficiency during pregnancy has been linked to perinatal adverse outcomes. Studies conducted to date have recommended assessing interactions with other vitamin D-related metabolites to clarify this subject. We aimed to evaluate the association of vitamin D deficiency during early pregnancy with preterm birth. Secondary outcomes included low birth weight and small for gestational age. Additionally, we explored the role that parathyroid hormone, calcium and phosphorus could play in the associations. We conducted a prospective cohort study comprising 289 pregnant women in a hospital in Granada, Spain. Participants were followed-up from weeks 10–12 of gestation to postpartum. Serum 25-hydroxyvitamin D, parathyroid hormone, calcium, and phosphorus were measured within the first week after recruitment. Pearson’s 2 test, Mann–Whitney U test, binary and multivariable logistic regression models were used to explore associations between variables and outcomes. 36.3% of the participants were vitamin D deficient (<20 ng/mL). 25-hydroxyvitamin D concentration was inversely correlated with parathyroid hormone ( = -0.146, p = 0.013). Preterm birth was associated with vitamin D deficiency in the multivariable model, being this association stronger amongst women with parathyroid hormone serum levels above the 80th percentile (adjusted odds ratio (aOR) = 6.587, 95% CI (2.049, 21.176), p = 0.002). Calcium and phosphorus were not associated with any studied outcome. Combined measurement of 25-hydroxyvitamin D and parathyroid hormone could be a better estimator of preterm birth than vitamin D in isolation. 2021-01-28T09:08:48Z 2021-01-28T09:08:48Z 2020-10-26 journal article Pérez-Castillo, Í. M., Rivero-Blanco, T., León-Ríos, X. A., Expósito-Ruiz, M., López-Criado, M. S., & Aguilar-Cordero, M. J. (2020). Associations of Vitamin D Deficiency, Parathyroid hormone, Calcium, and Phosphorus with Perinatal Adverse Outcomes. A Prospective Cohort Study. Nutrients, 12(11), 3279. [doi:10.3390/nu12113279] http://hdl.handle.net/10481/66091 10.3390/nu12113279 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Mdpi