Improving ductal carcinoma in situ classification by convolutional neural network with exponential linear unit and rank-based weighted pooling Zhang, Yu-Dong Gorriz Sáez, Juan Manuel Ductal carcinoma in situ Thermal images Deep learning Convolutional neural networks Breast thermography Exponential linear unit Rank-based weighted pooling Data augmentation Color jittering Visual question answering Ductal carcinoma in situ (DCIS) is a pre-cancerous lesion in the ducts of the breast, and early diagnosis is crucial for optimal therapeutic intervention. Thermography imaging is a non-invasive imaging tool that can be utilized for detection of DCIS and although it has high accuracy (~88%), it is sensitivity can still be improved. Hence, we aimed to develop an automated artificial intelligence-based system for improved detection of DCIS in thermographs. This study proposed a novel artificial intelligence based system based on convolutional neural network (CNN) termed CNN-BDER on a multisource dataset containing 240 DCIS images and 240 healthy breast images. Based on CNN, batch normalization, dropout, exponential linear unit and rank-based weighted pooling were integrated, along with L-way data augmentation. Ten runs of tenfold cross validation were chosen to report the unbiased performances. Our proposed method achieved a sensitivity of 94.08±1.22%, a specificity of 93.58±1.49 and an accuracy of 93.83±0.96. The proposed method gives superior performance than eight state-of-theart approaches and manual diagnosis. The trained model could serve as a visual question answering system and improve diagnostic accuracy. 2021-01-20T11:32:03Z 2021-01-20T11:32:03Z 2020-11 info:eu-repo/semantics/article Zhang, Y. D., Satapathy, S. C., Wu, D., Guttery, D. S., Górriz, J. M., & Wang, S. H. (2020). Improving ductal carcinoma in situ classification by convolutional neural network with exponential linear unit and rank-based weighted pooling. Complex & Intelligent Systems, 1-16. [https://doi.org/10.1007/s40747-020-00218-4] http://hdl.handle.net/10481/65582 10.1007/s40747-020-00218-4 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License Atribución 3.0 España Springer Nature