Quality and reporting of clinical guidelines for breast cancer treatment: A systematic review Maes Carballo, Marta Mignini, Luciano Martín Díaz, Manuel Bueno Cavanillas, Aurora Saeed Khan, Khalid Breast cancer Treatment Clinical practice guidelines Guidelines Consensus Agree II Right Appraisal instruments Quality of guidelines Background: High-quality, well-reported clinical practice guidelines (CPGs) and consensus statements (CSs) underpinned by systematic reviews are needed. We appraised the quality and reporting of CPGs and CSs for breast cancer (BC) treatment. Methods: Following protocol registration (Prospero no: CRD42020164801), CPGs and CSs on BC treatment were identified, without language restrictions, through a systematic search of bibliographic databases (MEDLINE, EMBASE, Web of Science, Scopus, CDSR) and online sources (12 guideline databases and 51 professional society websites) from January 2017 to June 2020. Data were extracted in duplicate assessing overall quality using AGREE II (% of maximum score) and reporting compliance using RIGHT (% of total 35 items); reviewer agreement was 98% and 96% respectively. Results: There were 59 relevant guidance documents (43 CPGs, 16 CSs), of which 20 used systematic reviews for evidence synthesis. The median overall quality was 54.0% (IQR 35.9e74.3) and the median overall reporting compliance was 60.9% (IQR 44.5e84.4). The correlation between quality and reporting was 0.9. Compared to CSs, CPGs had better quality (55.4% vs 44.2%; p ¼ 0.032) and reporting (67.18% vs 44.5%; p ¼ 0.005). Compared to subjective methods of evidence analysis, guidance documents that used systematic reviews had better quality (76.3% vs 51.4%; p ¼ 0.001) and reporting (87.1% vs 59.4%; p ¼ 0.001). Conclusion: The quality and reporting of CPGs and CSs in BC treatment were moderately strong. Systematic reviews should be used to improve the quality and reporting of CPGs and CSs. 2020-11-23T11:43:16Z 2020-11-23T11:43:16Z 2020-08-10 journal article Maes-Carballo, M., Mignini, L., Martín-Díaz, M., Bueno-Cavanillas, A., & Khan, K. S. (2020). Quality and reporting of clinical guidelines for breast cancer treatment: A systematic review. The Breast. [DOI: 10.1016/j.breast.2020.07.011] http://hdl.handle.net/10481/64442 10.1016/j.breast.2020.07.011 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ open access Atribución-NoComercial-SinDerivadas 3.0 España Elsevier