Fundamentals of light-cell–polymer interactions in photo-cross-linking based bioprinting Nieto, Daniel Marchal Corrales, Juan Antonio Jorge de Mora, Alberto Moroni, Lorenzo DATA AVAILABILITY The data that support the findings of this study are available within the article. Daniel Nieto thanks the support from the Xunta de Galicia, Spain, under the Galician Programme for Research Innovation and Growth 2011-2015 (I2C Plan). Lorenzo Moroni is grateful to the Dutch Province of Limburg and to the European Research Council starting grant “Cell Hybridge” (Grant No. 637308). This work was supported by Consejería de Economía, Conocimiento, Empresas y Universidad de la Junta de Andalucía and European Regional Development Funds (ERDF) (Project Nos. B-CTS-230-UGR18 and PY18–2470) and the Instituto de Salud Carlos III, ERDF funds (No. DTS19/00145). Biofabrication technologies that use light for polymerization of biomaterials have made significant progress in the quality, resolution, and generation of precise complex tissue structures. In recent years, the evolution of these technologies has been growing along with the development of new photocurable resins and photoinitiators that are biocompatible and biodegradable with bioactive properties. Such evolution has allowed the progress of a large number of tissue engineering applications. Flexibility in the design, scale, and resolution and wide applicability of technologies are strongly dependent on the understanding of the biophysics involved in the biofabrication process. In particular, understanding cell–light interactions is crucial when bioprinting using cell-laden biomaterials. Here, we summarize some theoretical mechanisms, which condition cell response during bioprinting using light based technologies. We take a brief look at the light–biomaterial interaction for a better understanding of how linear effects (refraction, reflection, absorption, emission, and scattering) and nonlinear effects (two-photon absorption) influence the biofabricated tissue structures and identify the different parameters essential for maintaining cell viability during and after bioprinting. 2020-11-20T10:23:45Z 2020-11-20T10:23:45Z 2020-10-12 info:eu-repo/semantics/article Nieto, Daniel Marchal Corrales, Juan Antonio Jorge de Mora, Alberto Moroni, Lorenzo. Fundamentals of light-cell–polymer interactions in photo-cross-linking based bioprinting. APL Bioengineering 4, 041502 (2020); [https://doi.org/10.1063/5.0022693] http://hdl.handle.net/10481/64396 10.1063/5.0022693 eng info:eu-repo/grantAgreement/EC/H2020/Cell Hybridge 637308 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España American Institute of Physics