<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/64157">
      <dc:title>Polymeric Bioadhesive Patch Based on Ketoprofen-Hydrotalcite Hybrid for Local Treatments</dc:title>
      <dc:creator>Pagano, Cinzia</dc:creator>
      <dc:creator>Viseras Iborra, César Antonio</dc:creator>
      <dc:subject>Hydrotalcite</dc:subject>
      <dc:subject>Ketoprofen</dc:subject>
      <dc:subject>Hybrid</dc:subject>
      <dc:subject>Photostability</dc:subject>
      <dc:subject>Hydrogel film</dc:subject>
      <dc:subject>Bioadhesion</dc:subject>
      <dc:description>Authors sincerely acknowledge Morena Nocchetti for X-ray patterns and registration and&#xd;
Marco Marani for technical assistance from the Department of Pharmaceutical Sciences. Authors wish to thank&#xd;
Simonetta De Angelis from ASL N. 1 (Città di Castello, Perugia, Italy), for providing pig skin samples.</dc:description>
      <dc:description>Ketoprofen (KET) represents one of the most common drugs used in the topical treatment of pain and inflammations. However, its potential is rather limited due to the very low solubility and photochemical instability. The local administration of KET by conventional products, such as gels, emulgels, creams, and foams, does not guarantee an efficacious and safe treatment because of its low absorption (due to low solubility) and its sensitivity to UV rays. The photodegradation of KET makes many photoproducts responsible for different adverse effects. In the present work, KET was intercalated into the lamellar anionic clay ZnAl-hydrotalcite (ZnAl-HTlc), obtaining the hybrid ZnAl-KET with improved stability to UV rays and water solubility in comparison to the crystalline form (not intercalated KET). The hybrid was then formulated in autoadhesive patches for local pain treatment. The patches were prepared by casting method starting from a hydrogel based on the biocompatible and bioadhesive polymer NaCMC (Sodium carboxymethycellulose) and glycerol as a plasticizing agent. The introduction of ZnAl-KET in the patch composition demonstrated the improvement in the mechanical properties of the formulation. Moreover, a sustained and complete KET release was obtained within 8 h. This allowed reducing the frequency of anti-inflammatory administration, compared to the conventional formulations</dc:description>
      <dc:date>2020-11-09T13:32:06Z</dc:date>
      <dc:date>2020-11-09T13:32:06Z</dc:date>
      <dc:date>2020-08-04</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>Pagano, C.; Latterini, L.; Di Michele, A.; Luzi, F.; Puglia, D.; Ricci, M.; Antonio Viseras Iborra, C.; Perioli, L. Polymeric Bioadhesive Patch Based on Ketoprofen-Hydrotalcite Hybrid for Local Treatments. Pharmaceutics 2020, 12, 733. [doi:10.3390/pharmaceutics12080733]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/64157</dc:identifier>
      <dc:identifier>10.3390/pharmaceutics12080733</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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