Study of weight and body mass index on graft loss after transplant over 5 years of evolution Liñán González, Antonio García Pérez, Raquel Bravo Soto, Juan Fernández Castillo, Rafael Anthropometry Obesity BMI Graft Loss Kidney transplantation Overweight Antonio Liñán González conceived paper, oversaw data collection, conducted data analysis, wrote manuscript and approved final version. Raquel García Pérez participated in study design, data analysis and interpretation, critically revised manuscript and approved final version. Juan Bravo Soto participated in study design, data analysis, and interpretation of data and revision of manuscript and approved final version. Rafael Fernández Castillo participated in study design, interpretation of data and revision of manuscript and approved final version. Patients frequently experience a weight gain after organ transplantation. This increase in weight is the result of multiple factors, and is usually intensified by glucocorticoids and immunosuppressive drugs. It can also delay graft function and cause serious health problems. The objective of this study was to study the obesity as well as its causes and consequences in kidney transplant patients. The sample population consisted of 282 renal transplant patients, 170 men and 112 women, 18-74 years of age, who were monitored over a period of five years. For the purposes of our research, the patients were divided into two groups: (1) normal weight 18.5 ≤ BMI <25; (2) overweight 25 ≤ BMI ≤30. The association between BMI as an independent variable and graft survival was determined by means of a Cox regression analysis. Overweight patients were characterized by a higher comorbidity prevalence. In the Cox multivariate analysis, the initial BMI, evaluated as a continuous variable continued to be an independent predictor of delayed graft function and chronic nephropathy. This study evaluated the BMI as a continuous value instead of a categorical value. In conclusion, our results suggest that an increase in BMI without categorical variation can be an independent risk factor for graft loss. Consequently, obesity prevention for renal transplant patients should include dietary counseling and management, moderate physical activity, and steroid minimization. 2020-10-28T11:13:09Z 2020-10-28T11:13:09Z 2020-08-27 info:eu-repo/semantics/article González, A. L., Pérez, R. G., Soto, J. B., & Castillo, R. F. (2020). Study of weight and body mass index on graft loss after transplant over 5 years of evolution. International Journal of Medical Sciences, 17(15), 2306. [DOI: 10.7150/ijms.47000] http://hdl.handle.net/10481/63929 10.7150/ijms.47000 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Ivyspring International Publisher