Characterization of non‑linear mechanical behavior of the cornea Ashofteh Yazdi, A. Melchor, Juan Torres, J. Faris, Inas Calleja, Alonso Rus Carlborg, Guillermo The objective of this study was to evaluate which hyperelastic model could best describe the nonlinear mechanical behavior of the cornea, in order to characterize the capability of the non-linear model parameters to discriminate structural changes in a damaged cornea. Porcine corneas were used, establishing two diferent groups: control (non-treated) and NaOH-treated (damaged) corneas (n= 8). NaOH causes a chemical burn to the corneal tissue, simulating a disease associated to structural damage of the stromal layer. Quasi-static uniaxial tensile tests were performed in nasaltemporal direction immediately after preparing corneal strips from the two groups. Three non-linear hyperelastic models (i.e. Hamilton-Zabolotskaya model, Ogden model and Mooney-Rivlin model) were ftted to the stress–strain curves obtained in the tensile tests and statistically compared. The corneas from the two groups showed a non-linear mechanical behavior that was best described by the Hamilton-Zabolotskaya model, obtaining the highest coefcient of determination (R2 > 0.95). Moreover, Hamilton-Zabolotskaya model showed the highest discriminative capability of the nonlinear model parameter (Parameter A) for the tissue structural changes between the two sample groups (p= 0.0005). The present work determines the best hyperelastic model with the highest discriminative capability in description of the non-linear mechanical behavior of the cornea. 2020-09-24T11:21:43Z 2020-09-24T11:21:43Z 2020-07-14 info:eu-repo/semantics/article Yazdi, A. A., Melchor, J., Torres, J., Faris, I., Callejas, A., Gonzalez-Andrades, M., & Rus, G. (2020). Characterization of non-linear mechanical behavior of the cornea. Scientific Reports, 10(1), 1-10. [https://doi.org/10.1038/s41598-020-68391-7] http://hdl.handle.net/10481/63536 10.1038/s41598-020-68391-7 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Nature Research