<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/63366">
      <dc:title>Characterization and Therapeutic Effect of a pH Stimuli Responsive Polymeric Nanoformulation for Controlled Drug Release</dc:title>
      <dc:creator>Cano-Cortés, Victoria</dc:creator>
      <dc:creator>Laz Ruiz, Jose Antonio</dc:creator>
      <dc:creator>Díaz Mochón, Juan José</dc:creator>
      <dc:creator>Sánchez Martín, Rosario María</dc:creator>
      <dc:subject>Covalent drug conjugation</dc:subject>
      <dc:subject>Therapeutic nanodevice</dc:subject>
      <dc:subject>Polymeric nanoparticles</dc:subject>
      <dc:subject>Cancer therapy</dc:subject>
      <dc:subject>Controlled drug delivery</dc:subject>
      <dc:description>Despite the large number of polymeric nanodelivery systems that have been recently&#xd;
developed, there is still room for improvement in terms of therapeutic efficiency. Most reported&#xd;
nanodevices for controlled release are based on drug encapsulation, which can lead to undesired drug&#xd;
leakage with a consequent reduction in efficacy and an increase in systemic toxicity. Herein, we present&#xd;
a strategy for covalent drug conjugation to the nanodevice to overcome this drawback. In particular,&#xd;
we characterize and evaluate an effective therapeutic polymeric PEGylated nanosystem for controlled&#xd;
pH-sensitive drug release on a breast cancer (MDA-MB-231) and two lung cancer (A549 and H520)&#xd;
cell lines. A significant reduction in the required drug dose to reach its half maximal inhibitory&#xd;
concentration (IC50 value) was achieved by conjugation of the drug to the nanoparticles, which&#xd;
leads to an improvement in the therapeutic index by increasing the efficiency. The genotoxic effect of&#xd;
this nanodevice in cancer cells was confirmed by nucleus histone H2AX specific immunostaining.&#xd;
In summary, we successfully characterized and validated a pH responsive therapeutic polymeric&#xd;
nanodevice in vitro for controlled anticancer drug release.</dc:description>
      <dc:date>2020-09-10T08:44:46Z</dc:date>
      <dc:date>2020-09-10T08:44:46Z</dc:date>
      <dc:date>2020-06-01</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Cano-Cortes, M. V., Laz-Ruiz, J. A., Diaz-Mochon, J. J., &amp; Sanchez-Martin, R. M. (2020). Characterization and Therapeutic Effect of a pH Stimuli Responsive Polymeric Nanoformulation for Controlled Drug Release. Polymers, 12(6), 1265. [doi: 10.3390/polym12061265]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/63366</dc:identifier>
      <dc:identifier>10.3390/polym12061265</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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