Neutrophil Extracellular Traps in Periodontitis Magán Fernández, Antonio Rasheed Al-Bakri, Sarmad Muayad O'Valle Ravassa, Francisco Javier Benavides Reyes, Cristina Abadía Molina, Francisco Mesa Aguado, Francisco Luis Innate immunity Periodontitis Neutrophil functions Neutrophil extracellular traps Neutrophils are key cells of the immune system and have a decisive role in fighting foreign pathogens in infectious diseases. Neutrophil extracellular traps (NETs) consist of a mesh of DNA enclosing antimicrobial peptides and histones that are released into extracellular space following neutrophil response to a wide range of stimuli, such as pathogens, host-derived mediators and drugs. Neutrophils can remain functional after NET formation and are important for periodontal homeostasis. Periodontitis is an inflammatory multifactorial disease caused by a dysbiosis state between the gingival microbiome and the immune response of the host. The pathogenesis of periodontitis includes an immune-inflammatory component in which impaired NET formation and/or elimination can be involved, contributing to an exacerbated inflammatory reaction and to the destruction of gingival tissue. In this review, we summarize the current knowledge about the role of NETs in the pathogenesis of periodontitis. 2020-09-02T10:02:30Z 2020-09-02T10:02:30Z 2020-06-19 journal article Magán-Fernández, A., Rasheed Al-Bakri, S. M., O’Valle, F., Benavides-Reyes, C., Abadía-Molina, F., & Mesa, F. (2020). Neutrophil Extracellular Traps in Periodontitis. Cells, 9(6), 1494. [doi: 10.3390/cells9061494] http://hdl.handle.net/10481/63265 10.3390/cells9061494 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI