Current Information and Asian Perspectives on Long-Chain Polyunsaturated Fatty Acids in Pregnancy, Lactation, and Infancy: Systematic Review and Practice Recommendations from an Early Nutrition Academy Workshop Koletzko, Berthold Campoy Folgoso, Cristina Arachidonic acid Eicosapentaenoic acid Docosahexaenoic acid Polyunsaturated fatty acids (PUFA) Nutrition in pregnancy Perinatal nutrition Infant's feeding Christopher Boey, Cristina Campoy, Namsoo Chang, Sadhana Joshi, Christine Prell, Maria Antonia Guillermo-Tuazon, Quak, Damayanti Rush Sjarif, and Sarayut Supapannachart report no conflicts of interest. Susan E. Carlson has received financial support from DSM, Mead Johnson Nutrition, Wyeth Nutrition, and Sequoia. Berthold Koletzko is a member of the National Breastfeeding Committee and tends to be biased towards breast-feeding. The Ludwig Maximilians University of Munich and its employee Berthold Koletzko have received support for scientific and educational activities from Abbott, Danone, DSM, Fonterra, Hipp, Mead Johnson, and Nestle, predominantly as part of publically funded research projects with support of the European Commission or German governmental research granting agencies. Saskia Osendarp worked for Unilever until January 2012. Yuichiro Yamashiro has received research support from Yakult Honsha Co., Ltd., Tokyo, Japan. The Early Nutrition Academy supported a systematic review of human studies on the roles of pre- and postnatal long-chain polyunsaturated fatty acids (LC-PUFA) published from 2008 to 2013 and an expert workshop that reviewed the information and developed recommendations, considering particularly Asian populations. An increased supply of n-3 LC-PUFA during pregnancy reduces the risk of preterm birth before 34 weeks of gestation. Pregnant women should achieve an additional supply ≥200 mg docosahexaenic acid (DHA)/day, usually achieving a total intake ≥300 mg DHA/day. Higher intakes (600-800 mg DHA/day) may provide greater protection against early preterm birth. Some studies indicate beneficial effects of pre- and postnatal DHA supply on child neurodevelopment and allergy risk. Breast-feeding is the best choice for infants. Breast-feeding women should get ≥200 mg DHA/day to achieve a human milk DHA content of ∼0.3% fatty acids. Infant formula for term infants should contain DHA and arachidonic acid (AA) to provide 100 mg DHA/day and 140 mg AA/day. A supply of 100 mg DHA/day should continue during the second half of infancy. We do not provide quantitative advice on AA levels in follow-on formula fed after the introduction of complimentary feeding due to a lack of sufficient data and considerable variation in the AA amounts provided by complimentary foods. Reasonable intakes for very-low-birth weight infants are 18-60 mg/kg/day DHA and 18-45 mg/kg/day AA, while higher intakes (55-60 mg/kg/day DHA, ∼1% fatty acids; 35-45 mg/kg/day AA, ∼0.6-0.75%) appear preferable. Research on the requirements and effects of LC-PUFA during pregnancy, lactation, and early childhood should continue. 2020-07-28T08:40:58Z 2020-07-28T08:40:58Z 2014 info:eu-repo/semantics/article Koletzko, B., Boey, C. C., Campoy, C., Carlson, S. E., Chang, N., Guillermo-Tuazon, M. A., ... & Su, Y. (2014). Current information and Asian perspectives on long-chain polyunsaturated fatty acids in pregnancy, lactation, and infancy: systematic review and practice recommendations from an early nutrition academy workshop. Annals of Nutrition and Metabolism, 65(1), 49-80. [https://doi.org/10.1159/000365767] http://hdl.handle.net/10481/63162 10.1159/000365767 eng http://creativecommons.org/licenses/by-nc/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial 3.0 España Karger