Chronic Fatigue, Physical Impairments and Quality of Life in Women with Endometriosis: A Case-Control Study Álvarez Salvago, Francisco Lara Ramos, Antonio Cantarero Villanueva, Irene Mazheika, Maryna Mundo López, Antonio Galiano Castillo, Noelia Fernández Lao, Carolina Arroyo Morales, Manuel Ocón Hernández, Olga Artacho Cordón, Francisco Chronic fatigue Endometriosis Health-related fitness Health-related quality of life Sleep quality The authors are indebted with all participants, without whom this work would not have been possible. We are grateful to Ana Yara Postigo-Fuentes for her assistance with the English language. This paper is part of the PhD thesis developed by A. Lara-Ramos in the Official Doctoral Programme in Clinical Medicine and Public Health of the University of Granada. Aim: To explore endometriosis-related fatigue (ERF), health-related fitness, sleep quality, and health-related quality of life (HRQoL) in women with endometriosis in comparison with matched controls. Methods: Twenty-five affected women and twenty-five age and height-matched women without endometriosis were included. ERF was assessed through the Piper Fatigue Scale; health-related fitness was assessed through the Schöber, flamingo, and 6-min walking tests and dynamometry; and body composition was assessed through impedanciometry. Self-perceived physical fitness, sleep quality, and HRQoL were assessed through the International Fitness Scale, the Pittsburgh Sleep Quality Index, and the 12-item Short Form Health Survey, respectively. Results: Affected women exhibited higher levels of ERF than controls, increased fat mass, and physical deconditioning (reduced back strength, lumbar flexibility, body balance, and functional capacity, p-values < 0.050). Moreover, cases also had poorer perceived physical fitness, sleep quality, and HRQoL (p-value < 0.050). Finally, we observed deteriorated health-related fitness, sleep quality, and HRQoL in those women with endometriosis with higher levels of ERF. Conclusions: This study constitutes the first evidence that women with endometriosis describe a generalized physical deconditioning, even more pronounced in affected women with higher levels of ERF. Further studies assessing the efficacy of rehabilitation interventions to face these physical impairments in women with endometriosis are warranted. 2020-07-27T11:45:31Z 2020-07-27T11:45:31Z 2020-05 journal article Álvarez-Salvago, F., Lara-Ramos, A., Cantarero-Villanueva, I., Mazheika, M., Mundo-López, A., Galiano-Castillo, N., ... & Artacho-Cordón, F. (2020). Chronic Fatigue, Physical Impairments and Quality of Life in Women with Endometriosis: A Case-Control Study. International Journal of Environmental Research and Public Health, 17(10), 3610. [DOI: 10.3390/ijerph17103610] http://hdl.handle.net/10481/63149 10.3390/ijerph17103610 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI