Effectiveness of Mediterranean Diet Implementation in Dry Eye Parameters: A Study of PREDIMED-PLUS Trial Molina-Leyva, Ignacio Molina Leyva, Alejandro Riquelme Gallego, Blanca Cano Ibáñez, Naomi García Molina, Laura Bueno Cavanillas, Aurora Mediterranean diet Dry eye Fatty acids Extra-virgin olive oil PREDIMED-PLUS trial This study was cofounded by grants from the Spanish Ministry of Science-Instituto de Salud Carlos III (PI17/00764) and FEDER funds. The authors wish to thank Ingrid de Ruiter, MBChB, Ph.D., for English language support. The purpose of this study is to evaluate the effect of a Mediterranean diet supplemented with extra virgin olive oil and nuts on dry eye parameters. The participants in this study were randomized into one of the two interventional arms: (1) a standard intervention group, a Mediterranean diet supplemented with extra virgin olive oil and nuts; and (2) an intensive intervention group, based on a hypocaloric Mediterranean diet and an intensive lifestyle program with physical activity and weight-loss goals. In both groups, common dry eye tests were conducted at baseline and after six months: the Ocular Surface Disease Index (OSDI), the Dry Eye Scoring System (DESS), tear break-up time (TBUT), the Schirmer’s test, and the Oxford staining grade. Sixty-seven eyes were examined. After six months, dry eye parameters improved in both groups; differences between groups were favorable for the intensive intervention group. The implementation of a Mediterranean diet pattern was beneficial for the selected patients with dry eye, and could be beneficial for patients with dry eye in general. Behavioral support for diet adherence and the promotion of healthy lifestyles (exercise) and weight loss (calorie restriction) have an added positive effect. 2020-07-22T11:47:43Z 2020-07-22T11:47:43Z 2020-05 info:eu-repo/semantics/article Molina-Leyva, I., Molina-Leyva, A., Riquelme-Gallego, B., Cano-Ibáñez, N., García-Molina, L., & Bueno-Cavanillas, A. (2020). Effectiveness of Mediterranean Diet Implementation in Dry Eye Parameters: A Study of PREDIMED-PLUS Trial. Nutrients, 12(5), 1289. [DOI: 10.3390/nu12051289] http://hdl.handle.net/10481/63108 10.3390/nu12051289 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI