Cardiorespiratory Fitness, Physical Activity, Sedentary Time and Its Association with the Atherogenic Index of Plasma in Chilean Adults: Influence of the Waist Circumference to Height Ratio Reyes Ferrada, Waleska Plaza Díaz, Julio Solis-Urra, Patricio Adiposity Cardiovascular risk Epidemiology Healthy lifestyles Lipid profile We thank all participants for their cooperation and the Chilean Health Ministry, the Department of Public Health, and the Pontificia Universidad Católica de Chile for designing and conducting the third National Health Survey (2016–2017). P.S.-U. was supported by a grant from ANID/BECAS Chile/72180543. Atherogenic index of plasma (AIP) is a novel biomarker related to cardiovascular disease (CVD). Cardiorespiratory fitness (CRF) and physical activity (PA) have an inverse relationship with the AIP, while sedentary time (ST) and fatness present a positive association. This study aimed to determine the combined and independent association of CRF, PA, and ST with the AIP, and additionally to establish the waist-to-height ratio (WHtR) mediation role. Data from the Chilean national health survey were used (4671 adults). A PACS (Physical Activity Cardiorespiratory Sedentary) score was created ranging from 0 to 3, indicating the number of positive recommendations met (PA, ST, and CRF). AIP was calculated (Log10 triglycerides/high-density lipoprotein-cholesterol). The combined analysis showed that compared to those with a PACS score of 0, those with a score of 1 or 2 did not present significantly reduced AIP values (adjusted by the WHtR); however, those with a score of 3 did (OR (odds ratio) = 0.50; 95% CI, 0.32 to 0.77; p < 0.001). Independent analysis showed that CRF seems to be the only variable that supports the combined result (β = −0.212; p < 0.001). Finally, the mediation analysis indicated that the WHtR mediated the association between CRF and the AIP in 34.2% of cases. Overall, only CRF had a significant and inverse association with the AIP. Nonetheless, around one-third of this beneficial relationship is affected by an elevated WHtR. 2020-07-22T11:46:41Z 2020-07-22T11:46:41Z 2020-04 info:eu-repo/semantics/article Reyes-Ferrada, W., Solis-Urra, P., Plaza-Díaz, J., Sadarangani, K. P., de Moraes Ferrari, G. L., Rodríguez-Rodríguez, F., & Cristi-Montero, C. (2020). Cardiorespiratory Fitness, Physical Activity, Sedentary Time and Its Association with the Atherogenic Index of Plasma in Chilean Adults: Influence of the Waist Circumference to Height Ratio. Nutrients, 12(5), 1250. [DOI: 10.3390/foods9050636] http://hdl.handle.net/10481/63106 10.3390/foods9050636 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI