<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/63103">
      <dc:title>Wound Healing Activity of Nanoclay/Spring Water Hydrogels</dc:title>
      <dc:creator>García Villén, Fátima</dc:creator>
      <dc:creator>Sánchez Espejo, Rita María</dc:creator>
      <dc:creator>Borrego Sánchez, Ana María</dc:creator>
      <dc:creator>Cerezo González, María Pilar</dc:creator>
      <dc:creator>Viseras Iborra, César Antonio</dc:creator>
      <dc:subject>Sepiolite</dc:subject>
      <dc:subject>Palygorskite</dc:subject>
      <dc:subject>Spring water</dc:subject>
      <dc:subject>Hydrogel</dc:subject>
      <dc:subject>Fibroblasts</dc:subject>
      <dc:subject>Biocompatibility</dc:subject>
      <dc:subject>Wound healing</dc:subject>
      <dc:description>This project was supported by an FPU grant (MECD), the Spanish research group CTS-946&#xd;
and the program for international mobility of PhD students (University of Granada). Special thanks to the&#xd;
Department of Drug Sciences of the University of Pavia (Italy).</dc:description>
      <dc:description>Background: hydrogels prepared with natural inorganic excipients and spring waters are&#xd;
commonly used in medical hydrology. Design of these clay-based formulations continues to be a&#xd;
field scarcely addressed. Safety and wound healing properties of different fibrous nanoclay/spring&#xd;
water hydrogels were addressed. Methods: in vitro biocompatibility, by means of MTT assay,&#xd;
and wound healing properties were studied. Confocal Laser Scanning Microscopy was used to&#xd;
study the morphology of fibroblasts during the wound healing process. Results: all the ingredients&#xd;
demonstrated to be biocompatible towards fibroblasts. Particularly, the formulation of nanoclays&#xd;
as hydrogels improved biocompatibility with respect to powder samples at the same concentration.&#xd;
Spring waters and hydrogels were even able to promote in vitro fibroblasts motility and, therefore,&#xd;
accelerate wound healing with respect to the control. Conclusion: fibrous nanoclay/spring water&#xd;
hydrogels proved to be skin-biocompatible and to possess a high potential as wound healing&#xd;
formulations. Moreover, these results open new prospects for these ingredients to be used in new&#xd;
therapeutic or cosmetic formulations.</dc:description>
      <dc:date>2020-07-22T11:44:58Z</dc:date>
      <dc:date>2020-07-22T11:44:58Z</dc:date>
      <dc:date>2020-05</dc:date>
      <dc:type>journal article</dc:type>
      <dc:identifier>García-Villén, F., Faccendini, A., Miele, D., Ruggeri, M., Sánchez-Espejo, R., Borrego-Sánchez, A., ... &amp; Sandri, G. (2020). Wound Healing Activity of Nanoclay/Spring Water Hydrogels. Pharmaceutics, 12(5), 467. [DOI: 10.3390/pharmaceutics12050467]</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/63103</dc:identifier>
      <dc:identifier>10.3390/pharmaceutics12050467</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>open access</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>