Optimized One vs One approach in multiclass classification for early Alzheimer’s Disease and Mild Cognitive Impairment diagnosis Jiménez Mesa, Carmen Illan, Ignacio A. Martín Martín, Alberto Castillo Barnes, Diego Martínez Murcia, Francisco Jesús Gorriz Sáez, Juan Manuel Alzheimer’s disease CAD Error correcting output codes Mild cognitive impairment Multiclass classification One versus One Partial Least Squares Random Forest Support vector machines The detection of Alzheimer’s Disease in its early stages is crucial for patient care and drugs development. Motivated by this fact, the neuroimaging community has extensively applied machine learning techniques to the early diagnosis problem with promising results. The organization of challenges has helped the community to address different raised problems and to standardize the approaches to the problem. In this work we use the data from international challenge for automated prediction of MCI from MRI data to address the multiclass classification problem. We propose a novel multiclass classification approach that addresses the outlier detection problem, uses pairwise t-test feature selection, project the selected features onto a Partial-Least-Squares multiclass subspace, and applies one-versus-one error correction output codes classification. The proposed method yields to an accuracy of 67 % in the multiclass classification, outperforming all the proposals of the competition. 2020-07-20T11:59:24Z 2020-07-20T11:59:24Z 2020 journal article Jiménez-Mesa, C., Illan, I. A., Martín-Martín, A., Castillo-Barnes, D., Martinez-Murcia, F. J., Ramirez, J., & Gorriz, J. M. (2020). Optimized One vs One approach in multiclass classification for early Alzheimer’s Disease and Mild Cognitive Impairment diagnosis. IEEE Access. [DOI: 10.1109/ACCESS.2020.2997736] http://hdl.handle.net/10481/63052 10.1109/ACCESS.2020.2997736 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Institute of Electrical and Electronics Engineers (IEEE)