Relationship between headaches and tinnitus in a Swedish study López Escámez, José Antonio Lugo, Alessandra The heterogeneity of tinnitus is likely accounting for the lack of efective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association between headaches and tinnitus (n=1,984 cases and 1,661 controls) and ii) investigate the phenotypic characteristics of tinnitus subjects with tinnitus (n=660) or without (n=1,879) headaches. In a multivariable logistic regression model, headache was signifcantly associated with any tinnitus (odds ratio, OR=2.61) and more so with tinnitus as a big problem (as measured by the tinnitus functional index, TFI≥48; OR=5.63) or severe tinnitus (using the tinnitus handicap inventory, THI ≥58; OR=4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26% and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and psychological characteristics difered between headache and non-headache subjects with any tinnitus. With increasing tinnitus severity, fewer diferences were found, the major ones being vertigo, neck pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could contribute to tinnitus distress and potentially its severity. 2020-07-17T12:03:05Z 2020-07-17T12:03:05Z 2020 info:eu-repo/semantics/article Lugo, A., Edvall, N. K., Lazar, A., Mehraei, G., Lopez-Escamez, J. A., Bulla, J., ... & Cederroth, C. R. (2020). Relationship between headaches and tinnitus in a Swedish study. Scientific Reports, 10(1), 1-12. [DOI: 10.1038/s41598-020-65395-1] http://hdl.handle.net/10481/63032 10.1038/s41598-020-65395-1 eng eu-repo/grantAgreement/EU/H2020/72204655 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Nature Research (part of Springer Nature)