Neck circumference is associated with adipose tissue content in thigh skeletal muscle in overweight and obese premenopausal women Arias Téllez, María José Ruiz Ruiz, Jonatan Neck circumference (NC) has been proposed as a simple and practical tool, independently associated with cardiometabolic risk factors. However, the association of NC with inter-muscular adipose tissue (IMAT) is still to be determined. We aimed to examine the association of NC with thigh IMAT, and visceral adipose tissue (VAT) measured with computed tomography (CT) in overweight/obese women. 142 premenopausal overweight and obese Caucasian women participated in this crosssectional study. NC was measured with an inextensible metallic tape above the thyroid cartilage according to International Society for Advancement of Kinanthropometry protocol. Thigh IMAT and VAT volumes were measured with a single cross-sectional CT. Regarding the covariates, fat mass (FM) was assessed with dual-energy x-ray absorptiometry and physical activity was objectively measured with accelerometry. NC was positively associated with thigh IMAT and VAT volumes (standardized β coefcient: β=0.45, P-value= ≤0.001, β=0.60, P=≤0.001; respectively), which persisted after adjusting for age, height, overall FM or moderate-to-vigorous physical activity. Our fndings show that NC is associated with thigh IMAT volume in overweight and obese premenopausal Caucasian women, regardless of the amount of lower-body fatness. These results suggest underscoring the relevance of NC as a marker of adipose tissue content in thigh skeletal muscle. 2020-07-17T12:02:07Z 2020-07-17T12:02:07Z 2020 journal article Tellez, M. J. A., Silva, A. M., Ruiz, J. R., Martins, S. S., Palmeira, A. L., Branco, T. L., ... & Sardinha, L. B. (2020). neck circumference is associated with adipose tissue content in thigh skeletal muscle in overweight and obese premenopausal women. Scientific Reports, 10(1), 1-6. [DOI: 10.1038/s41598-020-65204-9] http://hdl.handle.net/10481/63031 10.1038/s41598-020-65204-9 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Nature Research (part of Springer Nature)