Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of Other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study García Molina, Laura Castro Barquero, Sara Polyphenols Metabolic syndrome Mediterranean diet Glignans Stilbenes HDL-cholesterol We thank all the volunteers for their participation and medical professionals for their contribution to the PREDIMED-Plus trial. CIBEROBN, CIBERESP, and CIBERDEM are initiatives of the Instituto de Salud Carlos III (ISCIII), Madrid, Spain. A.T.R. and P.H.A. thanks the Ministry of Science Innovation and Universities for the Juan de la Cierva-formación contract. J.K. is grateful to the Fundación Instituto de Investigación Sanitaria Illes Balears (call financed by 2017annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands) for the postdoctoral contract for the ‘FOLIUM’ programme within the FUTURMed. Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c. 2020-06-10T12:37:49Z 2020-06-10T12:37:49Z 2020-03 journal article Castro-Barquero, S., Tresserra-Rimbau, A., Vitelli-Storelli, F., Doménech, M., Salas-Salvadó, J., Martín-Sánchez, V., ... & Romaguera, D. (2020). Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study. Nutrients, 12(3), 689. [doi:10.3390/nu12030689] http://hdl.handle.net/10481/62423 doi:10.3390/nu12030689 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI