COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression Llodra Calvo, Juan Carlos Carrouel, Florence COVID-19 2019-nCoV SARS-CoV-2 Oral cavity Mouthrinse β-cyclodextrins Citrox Viral load Microbiome Considered to be a major portal of entry for infectious agents, the oral cavity is directly associated with the evolutionary process of SARS-CoV-2 in its inhalation of ambient particles in the air and in expectorations. Some new generations of mouth rinses currently on the market have ingredients that could contribute to lower the SARS-CoV-2 viral load, and thus facilitate the fight against oral transmission. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain β-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of βCD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression. 2020-06-05T11:39:04Z 2020-06-05T11:39:04Z 2020 info:eu-repo/semantics/article Carrouel, F., Conte, M. P., Fisher, J., Gonçalves, L. S., Dussart, C., Llodra, J. C., & Bourgeois, D. (2020). COVID-19: A Recommendation to Examine the Effect of Mouthrinses with β-Cyclodextrin Combined with Citrox in Preventing Infection and Progression. [doi:10.3390/jcm9041126] http://hdl.handle.net/10481/62378 doi:10.3390/jcm9041126 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España MDPI