Supraclavicular skin temperature measured by iButtons and 18Ffluorodeoxyglucose uptake by brown adipose tissue in adults Martínez Téllez, Borja Manuel García Rivero, Yolanda Sánchez-Delgado, Guillermo Xu, Huiwen Amaro Gahete, Francisco José Acosta Manzano, Francisco Miguel Rensen, Patrick C. N. Boon, Mariëtte R. Llamas Elvira, José Manuel Ruiz Ruiz, Jonatan Brown fat Ibutton Data-logger Temperatus This study is part of a Ph.D. thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. Currently, 18 [F]-Fluorodeoxyglucose (18F-FDG) in combination with a positron emission tomography/computed tomography (PET/CT) scan analysis is the most commonly used method to quantify human BAT volume and activity. However, this technique presents several drawbacks which negatively affect participant's health. The aim of the present work is to determine whether supraclavicular skin temperature can be used as an indirect marker of cold-induced BAT and skeletal muscle 18F-FDG uptake in adults, while taking into account body composition. We performed a personalized cooling protocol just before an 18F-FDG-PET/CT scan, and we measured supraclavicular skin temperature before (in warm conditions) and after the cooling protocol in 88 adults (n = 57 women, mean age: 21.9 ± 2.1 years old, body mass index: 24.5 ± 4.3 km/m2). We found that supraclavicular skin temperature at the warm and cold periods was weakly and positively associated with BAT activity (SUVmean and SUVpeak: β = 3.000; R2 = 0.072; P = 0.022 and β = 2.448; R2 = 0.060; P = 0.021), but not with skeletal muscle 18F-FDG uptake, after controlling for body composition. We performed further analyses and the positive associations persisted only in the group of women. In conclusion, supraclavicular skin temperature in warm and cold conditions seems to be related with cold-induced 18F-FDG uptake by BAT only in women, although the low explained variance of these associations means that there are other factors involved in the supraclavicular skin temperature. 2020-05-21T12:33:54Z 2020-05-21T12:33:54Z 2019-04-16 info:eu-repo/semantics/article B. Martinez-Tellez, et al. Supraclavicular skin temperature measured by iButtons and 18Ffluorodeoxyglucose uptake by brown adipose tissue in adults. Journal of Thermal Biology 82 (2019) 178–185 [https://doi.org/10.1016/j.jtherbio.2019.04.006] http://hdl.handle.net/10481/62177 10.1016/j.jtherbio.2019.04.006 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Elsevier