Concurrent validity of supraclavicular skin temperature measured with iButtons and infrared thermography as a surrogate marker of brown adipose tissue Martínez Téllez, Borja Manuel Perez-Bey, Alejandro Sánchez-Delgado, Guillermo Acosta Manzano, Francisco Miguel Corral Pérez, Juan Amaro Gahete, Francisco José Alcantara, Juan M.A. Castro-Piñero, José Jiménez-Pavon, David Llamas Elvira, José Manuel Ruiz Ruiz, Jonatan Brown fat Skin temperature Thermoregulation We are grateful to Ms. Carmen Sainz-Quinn for assistance with the English language. We are grateful to Alberto Quesada-Aranda for helping with the development of the Temperatus software (Free trial in http://profth.ugr.es/temperatus). This study is part of a Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. Brown adipose tissue (BAT) thermogenic activity is commonly assessed with a positron emission tomography with computed tomography scan (PET/CT). This technique has several limitations and alternative techniques are needed. Supraclavicular skin temperature measured with iButtons and infrared thermography (IRT) has been proposed as an indirect marker of BAT activity. We studied the concurrent validity of skin temperature measured with iButtons vs. IRT and the association of supraclavicular skin temperature measured with iButtons and IRT with BAT. We measured skin temperature upon a shivering threshold test with iButtons and IRT in 6 different regions in 12 participants (n = 2 men). On a separate day, we determined supraclavicular skin temperature with an iButton and IRT after 2 h of a personalized cooling protocol. Thereafter, we quantified BAT volume and activity by PET/CT. We observed that the absolute differences between the devices were statistically different from 0 (all P < 0.05) after the shivering threshold test. Moreover, we did not find any association between supraclavicular skin temperature measured with iButtons or IRT and BAT 18F-FDG activity (r = −0.213; P = 0.530 and r = −0.079; P = 0.817). However, we observed a negative association of supraclavicular skin temperature measured by IRT with BAT 18F-FDG volume (r = −0.764; P = 0.006), but not with supraclavicular skin temperature measured with iButtons (r = −0.546; P = 0.082). In light of these results, we concluded that the measurement of skin temperature obtained by iButtons and IRT are not comparable. Furthermore, it seems that supraclavicular skin temperature is not associated with BAT 18F-FDG activity, but it appears to be negatively associated with BAT 18F-FDG volume in the case of IRT. 2020-05-21T11:21:47Z 2020-05-21T11:21:47Z 2019-04-20 info:eu-repo/semantics/article B. Martinez-Tellez, et al. Concurrent validity of supraclavicular skin temperature measured with iButtons and infrared thermography as a surrogate marker of brown adipose tissue. Journal of Thermal Biology 82 (2019) 186–196 [https://doi.org/10.1016/j.jtherbio.2019.04.009] http://hdl.handle.net/10481/62171 10.1016/j.jtherbio.2019.04.009 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Elsevier