<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/62075">
      <dc:title>Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles</dc:title>
      <dc:creator>Iglesias Salto, Guillermo Ramón</dc:creator>
      <dc:creator>Jabalera Ruz, Ylenia María</dc:creator>
      <dc:creator>Peigneux, Ana</dc:creator>
      <dc:creator>Checa Fernández, B. L.</dc:creator>
      <dc:creator>Delgado Mora, Ángel Vicente</dc:creator>
      <dc:creator>Jiménez López, Concepción</dc:creator>
      <dc:subject>Biomimetic magnetite</dc:subject>
      <dc:subject>Drug delivery</dc:subject>
      <dc:subject>Magnetic Hyperthermia</dc:subject>
      <dc:subject>Nanoparticles stability</dc:subject>
      <dc:description>In this work we report on the synthesis and characterization of magnetic nanoparticles of&#xd;
two distinct origins, one inorganic (MNPs) and the other biomimetic (BMNPs), the latter based on a&#xd;
process of bacterial synthesis. Each of these two kinds of particles has its own advantages when used&#xd;
separately with biomedical purposes. Thus, BMNPs present an isoelectric point below neutrality&#xd;
(around pH 4.4), while MNPs show a zero-zeta potential at pH 7, and appear to be excellent agents for&#xd;
magnetic hyperthermia. This means that the biomimetic particles are better suited to be loaded with&#xd;
drug molecules positively charged at neutral pH (notably, doxorubicin, for instance) and releasing it&#xd;
at the acidic tumor environment. In turn, MNPs may provide their transport capabilities under a&#xd;
magnetic field. In this study it is proposed to use a mixture of both kinds of particles at two different&#xd;
concentrations, trying to get the best from each of them. We study which mixture performs better from&#xd;
different points of view, like stability and magnetic hyperthermia response, while keeping suitable&#xd;
drug transport capabilities. This composite system is proposed as a close to ideal drug vehicle with&#xd;
added enhanced hyperthermia response.</dc:description>
      <dc:date>2020-05-14T11:28:33Z</dc:date>
      <dc:date>2020-05-14T11:28:33Z</dc:date>
      <dc:date>2019-06-11</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Iglesias, G. R., Jabalera, Y., Peigneux, A., Fernández, C., Luna, B., Delgado, Á. V., &amp; Jimenez-Lopez, C. (2019). Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles. Pharmaceutics, 11(6), 273.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/62075</dc:identifier>
      <dc:identifier>10.3390/pharmaceutics11060273</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
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