Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles Iglesias Salto, Guillermo Ramón Jabalera Ruz, Ylenia María Peigneux, Ana Checa Fernández, B. L. Delgado Mora, Ángel Vicente Jiménez López, Concepción Biomimetic magnetite Drug delivery Magnetic Hyperthermia Nanoparticles stability In this work we report on the synthesis and characterization of magnetic nanoparticles of two distinct origins, one inorganic (MNPs) and the other biomimetic (BMNPs), the latter based on a process of bacterial synthesis. Each of these two kinds of particles has its own advantages when used separately with biomedical purposes. Thus, BMNPs present an isoelectric point below neutrality (around pH 4.4), while MNPs show a zero-zeta potential at pH 7, and appear to be excellent agents for magnetic hyperthermia. This means that the biomimetic particles are better suited to be loaded with drug molecules positively charged at neutral pH (notably, doxorubicin, for instance) and releasing it at the acidic tumor environment. In turn, MNPs may provide their transport capabilities under a magnetic field. In this study it is proposed to use a mixture of both kinds of particles at two different concentrations, trying to get the best from each of them. We study which mixture performs better from different points of view, like stability and magnetic hyperthermia response, while keeping suitable drug transport capabilities. This composite system is proposed as a close to ideal drug vehicle with added enhanced hyperthermia response. 2020-05-14T11:28:33Z 2020-05-14T11:28:33Z 2019-06-11 journal article Iglesias, G. R., Jabalera, Y., Peigneux, A., Fernández, C., Luna, B., Delgado, Á. V., & Jimenez-Lopez, C. (2019). Enhancement of Magnetic Hyperthermia by Mixing Synthetic Inorganic and Biomimetic Magnetic Nanoparticles. Pharmaceutics, 11(6), 273. http://hdl.handle.net/10481/62075 10.3390/pharmaceutics11060273 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI