The mineralizing effect of zinc oxide-modified hydroxyapatite-based sealer on radicular dentin Toledano Pérez, Manuel Muñoz Soto, Esther Sánchez Aguilera, Fátima Osorio Ruiz, María Estrella Pérez-Álvarez, M.C. García-Menocal, J.A. Toledano Osorio, Manuel Osorio Ruiz, Raquel Hardness hydroxyapatite Raman remineralization root dentin zinc Objective To evaluate the remineralization ability of three endodontic sealer materials at different root dentin regions. Material and methods Cervical, medial and apical root dentin surfaces were treated with two experimental hydroxyapatite-based cements, containing sodium hydroxide (calcypatite) or zinc oxide (oxipatite); an epoxy resin-based canal sealer, AH Plus; and gutta-percha. Remineralization, at the inner and outer zones of dentin disk surfaces, was studied by nanohardness (Hi) and Raman analysis. Nano-roughness and collagen fibrils width measurements were performed. Numerical data, at 24 h or 12 m, were analyzed by ANOVA and Student-Newman-Keuls (P<0.05). Results At the outer and inner zones of cervical dentin treated with oxipatite, the highest Hi after 12 m of immersion was achieved. The same group showed the highest intensity of phosphate peak, markers for calcification and crystallinity. Nanoroughness was lower and fibrils diameter was higher at the inner zone of dentin treated with oxipatite. Dentin mineralization occurred in every region of root dentin treated with oxipatite and calcypatite, especially at inner zone of dentin after 12 m. Conclusions Oxipatite, reinforced the inner root zone at any third of radicular dentin, by increasing both nanohardness and remineralization. When using calcypatite, the highest nanohardness was found at the apical third of the inner root dentin, but the lowest mechanical performance was obtained at the cervical and the medial thirds of the roots. Therefore, application of oxipatite as sealing cement of root canals is recommended. Clinical relevance Oxipatite, when used as endodontic sealing material, strengthens radicular dentin. 2020-05-12T11:57:17Z 2020-05-12T11:57:17Z 2020 info:eu-repo/semantics/article Toledano M., Muñoz-Soto E., Aguilera F.S., Osorio E., Pérez-Álvarez M.C., García-Menocal J.A., Toledano-Osorio M., Osorio R. The mineralizing effect of zinc oxide-modified hydroxyapatite-based sealer on radicular dentin (2020) Clinical Oral Investigations, 24 (1), pp. 285-299. http://hdl.handle.net/10481/62001 https://doi.org/10.1007/s00784-019-02938-5 eng http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Atribución-NoComercial-SinDerivadas 3.0 España SPRINGER HEIDELBERG