<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/61938">
      <dc:title>Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease</dc:title>
      <dc:creator>Flook, Marisa</dc:creator>
      <dc:creator>Frejo, Lidia</dc:creator>
      <dc:creator>Espinosa Sánchez, Juan Manuel</dc:creator>
      <dc:creator>Pérez Carpena, Patricia</dc:creator>
      <dc:creator>López Escámez, José Antonio</dc:creator>
      <dc:subject>Vestibular Migraine</dc:subject>
      <dc:subject>Meniere Disease</dc:subject>
      <dc:subject>Differential diagnosis</dc:subject>
      <dc:description>Vestibular Migraine (VM) and Meniere’s Disease (MD) are episodic vestibular syndromes&#xd;
defined by a set of associated symptoms such as tinnitus, hearing loss or migraine&#xd;
features during the attacks. Both conditions may show symptom overlap and there is&#xd;
no biological marker to distinguish them. Two subgroups of MD patients have been&#xd;
reported, according to their IL-1b profile. Therefore, considering the clinical similarity&#xd;
between VM and MD, we aimed to investigate the cytokine profile of MD and VM&#xd;
as a means to distinguish these patients. We have also carried out gene expression&#xd;
microarrays and measured the levels of 14 cytokines and 11 chemokines in 129 MD&#xd;
patients, 82 VM patients, and 66 healthy controls. Gene expression profile in peripheral&#xd;
blood mononuclear cells (PBMC) showed significant differences in MD patients with high&#xd;
and low basal levels of IL- 1b and VMpatients.MD patients with high basal levels of IL- 1b&#xd;
(MDH) had overall higher levels of cytokines/chemokines when compared to the other&#xd;
subsets. CCL4 levels were significantly different between MDH, MD with low basal levels&#xd;
of IL- 1b (MDL), VM and controls. Logistic regression identified IL- 1b, CCL3, CCL22, and&#xd;
CXCL1 levels as capable of differentiating VM patients from MD patients (area under the&#xd;
curve = 0.995), suggesting a high diagnostic value in patients with symptoms overlap.</dc:description>
      <dc:date>2020-05-11T11:58:53Z</dc:date>
      <dc:date>2020-05-11T11:58:53Z</dc:date>
      <dc:date>2019-06-04</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Flook M, Frejo L, Gallego-Martinez A, Martin-Sanz E, Rossi-Izquierdo M, Amor-Dorado JC, Soto-Varela A, Santos-Perez S, Batuecas-Caletrio A, Espinosa-Sanchez JM, Pérez-Carpena P, Martinez-Martinez M, Aran I and Lopez-Escamez JA (2019) Differential Proinflammatory Signature in Vestibular Migraine and Meniere Disease. Front. Immunol. 10:1229.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/61938</dc:identifier>
      <dc:identifier>10.3389/fimmu.2019.01229</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>Frontiers in Media</dc:publisher>
   </ow:Publication>
</rdf:RDF>