Net contribution and predictive ability of the CUN-BAE body fatness index in relation to cardiometabolic conditions Davila Batista, Verónica Olmedo Requena, María Rocío Body fatness Metabolic syndrome Hypertension Diabetes Background The CUN-BAE (Clínica Universidad de Navarra-Body adiposity estimator) index is an anthropometric index based on age, sex and body mass index (BMI) for a refined prediction of body fatness in adults. CUN-BAE may help detect metabolically unhealthy individuals with otherwise normal weight according to BMI or waist circumference (WC). The aim of this study was to evaluate whether CUN-BAE, independent of its components (BMI, age and sex), was associated with cardiometabolic conditions including arterial hypertension, diabetes mellitus and metabolic syndrome (MetS). Methods The ENRICA study was based on a cross-sectional sample of non-institutionalized men and women representative of the adult Spanish population. Body weight, height, and WC were measured in all participants. The residual of CUN-BAE (rCUN-BAE), i.e. the part of the index not explained by its components, was calculated. The associations of CUN-BAE, rCUN-BAE, BMI and WC with hypertension, diabetes and MetS were analysed by multivariate logistic regression, and the Akaike information criterion (AIC) was calculated. Results The sample included 12,122 individuals. rCUN-BAE was associated with hypertension (OR 1.14, 95% CI 1.07–1.21) and MetS (OR 1.48, 1.37–1.60), but not with diabetes (OR 1.05, 0.94–1.16). In subjects with a BMI < 25 kg/m2, CUN-BAE was significantly associated with all three outcome variables. CUN-BAE was more strongly associated with the cardiometabolic conditions than BMI and WC and fit similar AICs. Conclusions The CUN-BAE index for body fatness was positively associated with hypertension, diabetes and MetS in adults independent of BMI or WC. CUN-BAE may help to identify individuals with cardiometabolic conditions beyond BMI, but this needs to be confirmed in prospective settings. 2020-05-05T11:49:56Z 2020-05-05T11:49:56Z 2018-06-11 journal article Davila Batista, Verónica, et al. Net contribution and predictive ability of the CUN-BAE body fatness index in relation to cardiometabolic conditions. European Journal of Nutrition (2019) 58:1853–1861 http://hdl.handle.net/10481/61812 10.1007/s00394-018-1743-9 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Springer Nature