Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the End EA Study Martín Peinado, Francisco Lendínez Romero, Inmaculada Sotelo, Rafael Iribarne Durán, Luz María Fernández Parra, Jorge Vela Soria, Fernando Olea Serrano, Nicolás Fernández Cabrera, Mariana Fátima Freire, Carmen León, Josefa Pérez Cabrera, Beatriz Ocón Hernández, Olga Artacho Cordón, Francisco Endocrine disruption Bisphenol-A Bisphenol-F Bisphenol-S Aim: The aim of this study was to explore associations of urinary concentrations of bisphenols A (BPA), S (BPS), and F (BPF) and of thiobarbituric acid reactive substances (TBARS) with the risk of endometriosis in women of childbearing age. Results: After adjustment for urinary creatinine, age, BMI, parity, and residence, endometriosis risk was increased with each 1 log unit of BPA [OR 1.5; 95%CI 1.0–2.3] and Sbisphenols [OR 1.5; 95%CI 0.9–2.3] but was not associated with the presence of BPS and BPF. Classification of the women by tertiles of exposure revealed statistically significant associations between endometriosis risk and the second tertile of exposure to BPA [OR 3.7; 95%CI 1.3–10.3] and Sbisphenols [OR 5.4; 95%CI 1.9–15.6]. In addition, TBARS concentrations showed a close-to-significant relationship with increased endometriosis risk [OR 1.6; 95%CI 1.0–2.8], and classification by TBARS concentration tertile revealed that the association between endometriosis risk and concentrations of BPA [OR 2.0; 95%CI 1.0–4.1] and Sbisphenols [OR 2.2; 95%CI 1.0–4.6] was only statistically significant for women in the highest TBARS tertile (>4.23 uM). Conclusion: Exposure to bisphenols may increase the risk of endometriosis, and oxidative stress may play a crucial role in this association. Further studies are warranted to verify these findings. 2020-05-04T11:46:08Z 2020-05-04T11:46:08Z 2020-02-13 journal article Peinado, F. M., Lendínez, I., Sotelo, R., Iribarne-Durán, L. M., Fernández-Parra, J., Vela-Soria, F., ... & Pérez-Cabrera, B. (2020). Association of Urinary Levels of Bisphenols A, F, and S with Endometriosis Risk: Preliminary Results of the EndEA Study. International journal of environmental research and public health, 17(4), 1194. http://hdl.handle.net/10481/61764 10.3390/ijerph17041194 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI