Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review Torres, Marta Dessaux, Yves Llamas Company, Inmaculada Quorum sensing Quorum quenching Marine habitat Saline environment Hypersaline habitat Marine pathogens Saline environments, such as marine and hypersaline habitats, are widely distributed around the world. They include sea waters, saline lakes, solar salterns, or hypersaline soils. The bacteria that live in these habitats produce and develop unique bioactive molecules and physiological pathways to cope with the stress conditions generated by these environments. They have been described to produce compounds with properties that differ from those found in non-saline habitats. In the last decades, the ability to disrupt quorum-sensing (QS) intercellular communication systems has been identified in many marine organisms, including bacteria. The two main mechanisms of QS interference, i.e., quorum sensing inhibition (QSI) and quorum quenching (QQ), appear to be a more frequent phenomenon in marine aquatic environments than in soils. However, data concerning bacteria from hypersaline habitats is scarce. Salt-tolerant QSI compounds and QQ enzymes may be of interest to interfere with QS-regulated bacterial functions, including virulence, in sectors such as aquaculture or agriculture where salinity is a serious environmental issue. This review provides a global overview of the main works related to QS interruption in saline environments as well as the derived biotechnological applications. 2020-04-27T11:42:16Z 2020-04-27T11:42:16Z 2019-03-25 journal article Torres, M., Dessaux, Y., & Llamas, I. (2019). Saline environments as a source of potential quorum sensing disruptors to control bacterial infections: A review. Marine drugs, 17(3), 191. http://hdl.handle.net/10481/61614 10.3390/md17030191 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España MDPI