Association Between the Use of a Mobile Health Strategy App and Biological Changes in Breast Cancer Survivors: Prospective Pre-Post Study Lozano Lozano, Mario Melguizo Rodríguez, Lucía Raquel Fernández Lao, Carolina Galiano Castillo, Noelia Cantarero Villanueva, Irene Martín Martín, Lydia María Arroyo Morales, Manuel mHealth C-reactive protein Low-grade inflammatory The objectives of this study were to: (1) check whether it is feasible to find changes in inflammation biomarkers through an mHealth strategy app as a delivery mechanism of an intervention to monitor energy balance; and (2) discover potential predictors of change of these markers in breast cancer survivors (BCSs). Analyzing changes in inflammatory biomarker concentrations after using the mHealth app, differences between preassessment CRP (4899.04 pg/ml; SD 1085.25) and IL-6 (87.15 pg/ml; SD 33.59) and postassessment CRP (4221.24 pg/ml; SD 911.55) and IL-6 (60.53 pg/ml; SD 36.31) showed a significant decrease in both markers, with a mean difference of –635.25 pg/ml (95% CI –935.65 to –334.85; P<.001) in CRP and –26.61 pg/ml (95% CI –42.51 to –10.71; P=.002) in IL-6. Stepwise regression analyses revealed that changes in global quality of life, as well as uMARS score and hormonal therapy, were possible predictors of change in CRP concentration after using the mHealth app. In the same way, the type of tumor removal surgery conducted, as well as changes in weight and pain score, were possible predictors of change in IL-6 concentration after using the app. In conclusion, through the results of this study, we hypothesize that there is a possible association between an mHealth energy balance monitoring strategy and biological changes in BCSs. These changes could be explained by different biopsychosocial parameters, such as the use of the application itself, quality of life, pain, type of tumor removal surgery, hormonal treatment or obesity. 2020-04-22T11:44:10Z 2020-04-22T11:44:10Z 2019 info:eu-repo/semantics/article Lozano-Lozano, M., Melguizo-Rodríguez, L., Fernández-Lao, C., Galiano-Castillo, N., Cantarero-Villanueva, I., Martín-Martín, L., & Arroyo-Morales, M. (2019). Association Between the Use of a Mobile Health Strategy App and Biological Changes in Breast Cancer Survivors: Prospective Pre-Post Study. Journal of medical Internet research, 21(8), e15062. http://hdl.handle.net/10481/61483 10.2196/15062 eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España JMIR Publications, Inc