<rdf:RDF xmlns:rdf="http://www.openarchives.org/OAI/2.0/rdf/" xmlns:ow="http://www.ontoweb.org/ontology/1#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:ds="http://dspace.org/ds/elements/1.1/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:doc="http://www.lyncode.com/xoai" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/rdf/ http://www.openarchives.org/OAI/2.0/rdf.xsd">
   <ow:Publication rdf:about="oai:digibug.ugr.es:10481/61426">
      <dc:title>Comparative Assessment of Phytochemical Profiles of Comfrey (Symphytum offcinale L.) Root Extracts Obtained by Different Extraction Techniques</dc:title>
      <dc:creator>Nastic, Natasa</dc:creator>
      <dc:creator>Borras Linares, María Isabel</dc:creator>
      <dc:creator>Lozano Sánchez, Jesús</dc:creator>
      <dc:creator>Svarc Gajic, Jaroslava</dc:creator>
      <dc:creator>Segura Carretero, Antonio</dc:creator>
      <dc:subject>Comfrey (Symphytum offcinale L.) root</dc:subject>
      <dc:subject>Maceration</dc:subject>
      <dc:subject>Phytochemical compounds</dc:subject>
      <dc:description>In this work a comparative study on phytochemical profiles of comfrey root&#xd;
extracts obtained by different extraction approaches has been carried out. Chemical profiles&#xd;
of extracts obtained by supercritical fluid (SFE), pressurized liquid (PLE), and conventional&#xd;
solid/liquid extraction were compared and discussed. Phytochemical composition was assessed by&#xd;
high-performance liquid chromatography coupled with electrospray time-of-flight mass spectrometry&#xd;
(HPLC-ESI-QTOF-MS/MS) identifying 39 compounds reported for the first time in comfrey root, mainly&#xd;
phenolic acids and fatty acids. The influence of different extraction parameters on phytochemical&#xd;
profiles of S. offcinale root was investigated for all applied techniques. PLE and maceration, using&#xd;
alcohol-based solvents (aqueous methanol or ethanol), were shown to be more effcient in the recovery&#xd;
of more polar compounds. Greater numbers of phenolics were best extracted by PLE using 85%&#xd;
EtOH at 63 ºC. The use of SFE and 100% acetone for 30 min enabled good recoveries of nonpolar&#xd;
compounds. SFE using 15% EtOH as a cosolvent at 150 bar produced the best recoveries of a&#xd;
significant number of fatty acids. The main compositional differences between extracts obtained&#xd;
by different extraction techniques were assigned to the solvent type. Hence, these results provided&#xd;
comprehensive approaches for treating comfrey root enriched in different phytochemicals, thereby&#xd;
enhancing its bioaccessibility.</dc:description>
      <dc:date>2020-04-21T11:56:19Z</dc:date>
      <dc:date>2020-04-21T11:56:19Z</dc:date>
      <dc:date>2020-02-14</dc:date>
      <dc:type>info:eu-repo/semantics/article</dc:type>
      <dc:identifier>Nastić, N., Borrás-Linares, I., Lozano-Sánchez, J., Švarc-Gajić, J., &amp; Segura-Carretero, A. (2020). Comparative Assessment of Phytochemical Profiles of Comfrey (Symphytum officinale L.) Root Extracts Obtained by Different Extraction Techniques. Molecules, 25(4), 837.</dc:identifier>
      <dc:identifier>http://hdl.handle.net/10481/61426</dc:identifier>
      <dc:identifier>10.3390/molecules25040837</dc:identifier>
      <dc:language>eng</dc:language>
      <dc:rights>http://creativecommons.org/licenses/by/3.0/es/</dc:rights>
      <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
      <dc:rights>Atribución 3.0 España</dc:rights>
      <dc:publisher>MDPI</dc:publisher>
   </ow:Publication>
</rdf:RDF>