Association between sleep quality and time with energy metabolism in sedentary adults Jurado Fasoli, Lucas Mochón Benguigui, Sol Castillo Garzón, Manuel Amaro Gahete, Francisco José The authors would like to thank all the participants that took part of the study for their time and effort. This study is part of a Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Spain. We are grateful to Dr. Ángel Gutiérrez and Alejandro De la O for all their support in the study. We are grateful to Ms. Ana Yara Postigo-Fuentes for her assistance with the English language. The aim of the present study was to investigate the relationship of sleep quality and time with basal metabolic rate (BMR) and fuel oxidation in basal conditions and during exercise in sedentary middleaged adults. We also studied the mediation role of dietary intake and adherence to the traditional Mediterranean Diet in the relationship between sleep parameters and energy metabolism parameters.A secondary analysis of the FIT-AGEING study was undertaken. 70 middle-aged sedentary adults (40–65 years old) participated in the present study. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) and wrist accelerometers (ActiSleep, Actigraph, Pensacola, Florida, USA) for 7 consecutive days. BMR was measured with indirect calorimetry and fuel oxidation was estimated through stoichiometric equations. Maximal fat oxidation was determined by a walking graded exercise test and dietary intake with 24 h recalls. Adherence to the traditional Mediterranean diet was assessed through the PREDIMED questionnaire. PSQI global score (poor sleep quality) was associated with lower basal fat oxidation (BFox), both expressed in g/min and as a percentage of BMR, independently of confounders. We did not find any association between other sleep and energy metabolism parameters. No mediating role of the dietary intake or PREDIMED global score was observed in the association of PSQI and BFox. In conclusion, our study showed that a subjective poor sleep quality was associated with lower BFox, which is not mediated by dietary intake in sedentary adults. 2020-04-15T08:21:45Z 2020-04-15T08:21:45Z 2020-03-12 journal article Jurado-Fasoli, L., Mochon-Benguigui, S., Castillo, M.J. et al. Association between sleep quality and time with energy metabolism in sedentary adults. Sci Rep 10, 4598 (2020). [https://doi.org/10.1038/s41598-020-61493-2] http://hdl.handle.net/10481/61210 10.1038/s41598-020-61493-2 eng http://creativecommons.org/licenses/by/3.0/es/ open access Atribución 3.0 España Springer Nature