Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyses Martínez Téllez, Borja Manuel Sánchez-Delgado, Guillermo Boon, Mariëtte R. Rensen, Patrick C. N. Llamas Elvira, José Manuel Ruiz Ruiz, Jonatan Brown fat Hounsfield units Standardized uptake value Cold exposure Procedures: We measured 125 individuals after a personalized cooling protocol with a static [18F]FDG-PET/CT scan. We quantified BAT using different combination of threshold in every single HU for all participants. Results: We observed that the SUV threshold influences BAT quantification by [18F]FDG-PET/ CT scans more than the HU range. We found that the range from − 50 to − 10 HU had the highest proportion of total BAT volume (43.2 %), which represents 41.4 % of the total BAT metabolic activity in our cohort. We also observed that BAT volume was not different between categories of body mass index, as well as BAT activity (SUVmean). In addition, BAT was less dense in women than in men, although the BAT activity (SUVmean) was higher in all ranges of HU. We also observed that the radiodensity of BAT located in the cervical area was mainly in the range from − 50 to − 10 HU. Conclusion: Therefore, all future human studies using static [18F]FDG-PET/CT scans should include BAT in the radiodensity range from − 50 to − 10 HU. 2020-04-14T11:49:33Z 2020-04-14T11:49:33Z 2020 info:eu-repo/semantics/article Martinez-Tellez, B., Sanchez-Delgado, G., Boon, M. R., Rensen, P. C., Llamas-Elvira, J. M., & Ruiz, J. R. (2020). Distribution of brown adipose tissue radiodensity in young adults: implications for cold [18 F] FDG-PET/CT analyses. Molecular Imaging and Biology, 22(2), 425-433. http://hdl.handle.net/10481/61179 10.1007/s11307-019-01381-y eng http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Atribución 3.0 España Springer Nature